ʻO Cloning a synthesizing virus: He ala wikiwiki e pale ai i nā maʻi maʻi e hiki mai ana

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  Quantumrun Foresight
• September 29, 2022

Hōʻuluʻulu manaʻo

Ua alakaʻi nā maʻi maʻi i nā holomua i ka cloning virus no ka ʻike wikiwiki a me ka hoʻomohala ʻana i ka maʻi. ʻOiai ʻo ka noiʻi hou e pili ana i nā ʻano hana hou e like me ka hoʻohana ʻana i ka hū no ka replication SARS-CoV-2, ke hoʻomau nei ka hopohopo no ka palekana a me ke kaua olaola. Hiki i kēia mau mea hoʻomohala ke alakaʻi i nā holomua i ka lāʻau lapaʻau pilikino, ka mahiʻai, a me ka hoʻonaʻauao, e hoʻomohala ana i kahi wā e hiki mai ana me nā ʻoihana olakino maikaʻi a me ka biotechnology.

Hoʻopili a hoʻohui i nā pōʻaiapili virus

Ua hoʻoweliweli mau nā maʻi viral i nā kānaka. ʻO kēia mau maʻi pathogenic i hoʻopilikia nui i ka mōʻaukala, e pāʻani pinepine ana i kahi kuleana nui i ka hopena o nā kaua a me nā hanana honua ʻē aʻe. ʻO nā moʻolelo o nā maʻi maʻi maʻi, e like me ka liʻiliʻi liʻiliʻi, ka ʻāʻī, HIV (human immunodeficiency virus), SARS-CoV (severe acute respiratory syndrome coronavirus), ka maʻi maʻi influenza 1918, a me nā mea ʻē aʻe, e kākau i nā hopena pōʻino o kēia mau maʻi. Ua alakaʻi kēia mau maʻi maʻi maʻi i nā ʻepekema a puni ka honua e clone a synthesize i nā maʻi e ʻike koke iā lākou a hana i nā lāʻau lapaʻau kūpono a me nā antidotes. 

I ka hū ʻana o ka maʻi maʻi COVID-19 i ka makahiki 2020, ua hoʻohana nā mea noiʻi honua i ka cloning e aʻo ai i ka ʻano genetic o ka maʻi. Hiki i nā ʻepekema ke humuhumu i nā ʻāpana DNA e hana hou i kahi genome viral a hoʻokomo iā lākou i loko o ka bacteria. Eia naʻe, ʻaʻole kūpono kēia ʻano no nā maʻi āpau - ʻoi aku ka coronavirus. No ka mea he nui nā genome nā coronaviruses, he mea paʻakikī kēia i ka maʻi bacteria e hoʻopili pono. Eia hou, hiki i nā ʻāpana o ka genome ke paʻa ʻole a i ʻole nā ​​​​mea ʻawaʻawa i ka bacteria—ʻoiai ʻaʻole maopopo loa ke kumu. 

Ma ka hoʻohālikelike ʻana, ke hoʻoikaika nei ka cloning a me ka synthesizing virus i ka hoʻoikaika kaua biological (BW). Hoʻokuʻu ke kaua olaola i nā microorganism a i ʻole nā ​​​​mea ʻawaʻawa e manaʻo nei e pepehi, hoʻopau, a hoʻoweliweli paha i ka ʻenemi i ka wā e hoʻopau ana i nā ʻoihana aupuni i nā mea liʻiliʻi. Hoʻokaʻawale ʻia kēia mau microorganisms he mau mea kaua no ka luku nui ʻana no ka mea hiki i nā mea liʻiliʻi ke hoʻohua i nā mea make. 

Ka hopena hoʻopilikia

I ka makahiki 2020, i ka heihei e hoʻomohala i kahi kano a i ʻole ka mālama ʻana no COVID-19, ua huli nā ʻepekema mai ke Kulanui o Bern i Switzerland i kahi mea hana maʻamau: hū. ʻAʻole like me nā maʻi ʻē aʻe, ʻaʻole hiki ke ulu ʻia ʻo SARS-CoV-2 i loko o nā cell kanaka i loko o ka lab, e paʻakikī ana ke aʻo ʻana. Akā ua hoʻomohala ka hui i kahi ala wikiwiki a maikaʻi hoʻi o ka cloning a synthesizing i ka maʻi me ka hoʻohana ʻana i nā cell yeast.

ʻO ke kaʻina hana, i wehewehe ʻia i loko o kahi pepa i paʻi ʻia ma ka puke moʻolelo ʻepekema ʻo Nature, ua hoʻohana i ka hoʻohui hou ʻana e pili ana i ka hoʻololi ʻana (TAR) e hoʻohui i nā ʻāpana DNA pōkole i loko o nā chromosomes holoʻokoʻa i loko o nā keena hū. Ua ʻae kēia ʻenehana i ka poʻe ʻepekema e wikiwiki a maʻalahi hoʻi i ka genome virus. Ua hoʻohana ʻia ke ʻano hana e clone i kahi mana o ka maʻi e hoʻopili ai i kahi protein reporter fluorescent, e ʻae ana i nā ʻepekema e nānā i nā lāʻau lapaʻau no ko lākou hiki ke pale i ka maʻi.

ʻOiai ke hāʻawi nei kēia ʻike i nā pono he nui ma mua o nā hana cloning kuʻuna, loaʻa pū kekahi mau pilikia. Hiki ke hoʻolaha ʻia nā maʻi hū i loko o ke kanaka, a aia ka pilikia e pakele ai kahi maʻi ʻenekinia mai kahi lab. Eia nō naʻe, manaʻo ka poʻe ʻepekema ʻo ke kaʻina hana cloning e hāʻawi i kahi mea hana ikaika no ka hoʻopili wikiwiki ʻana i nā maʻi maʻi a me ka hoʻomohala ʻana i nā lāʻau lapaʻau a i ʻole nā ​​​​lāʻau lapaʻau. Eia hou, ke noiʻi nei nā mea noiʻi i ka hoʻokō ʻana o TAR e hoʻopaʻa i nā maʻi ʻē aʻe, me MERS (Middle East Respiratory Syndrome) a me Zika.

Nā hopena o ka cloning a me ka synthesizing virus

ʻO nā hopena nui aʻe o ka cloning a me ka synthesizing virus hiki ke komo: 

• Ke hoʻomau nei i ka noiʻi ʻana i nā maʻi maʻi e kū mai ana, e hiki ai i nā aupuni ke hoʻomākaukau no nā maʻi maʻi a i ʻole nā ​​maʻi maʻi.
• ʻO Biopharma ka wikiwiki i ka hoʻomohala ʻana i ka lāʻau lapaʻau a me ka hana ʻana i nā maʻi viral.
• ʻO ka hoʻohana nui ʻana i ka cloning virus e ʻike i nā mea kaua ola. Eia nō naʻe, hiki i kekahi mau hui ke hana like no ka hoʻomohala ʻana i nā mea ʻawaʻawa maikaʻi aʻe.
• Ke koi nui ʻia nei nā aupuni e ʻike e pili ana i kāna mau noiʻi virology i hoʻopaʻa kālā ʻia a me ka hana hou ʻana i loko o kā lākou labs, me nā hoʻolālā contingency no ka wā e pakele ai kēia mau maʻi.
• ʻOi aku ka nui o ka lehulehu a me nā hoʻopukapuka pilikino i ka noiʻi cloning virus. Hiki i kēia mau papahana ke alakaʻi i ka hoʻonui ʻana i ka hana ma ka ʻāpana.
• ʻO ka hoʻonui ʻana i ke kahua o ka lāʻau lapaʻau pilikino, ka hoʻopili ʻana i nā lāʻau lapaʻau i nā profile genetic pilikino a me ka hoʻonui ʻana i ka pono o nā maʻi viral.
• Ka hoʻomohala ʻana i nā ʻano hana biocontrol mahiʻai ʻoi aku ka pololei, hiki ke hōʻemi i ka hilinaʻi ʻana i nā pesticides kemika a me ka hoʻoulu ʻana i ka mahiʻai hoʻomau.
• Hoʻokomo nā ʻoihana hoʻonaʻauao i ka biotechnology kiʻekiʻe i loko o ka curricula, e alakaʻi ana i kahi limahana akamai i ka virology a me nā genetics.

Nā nīnau e noʻonoʻo ai

• Pehea ʻoe e manaʻo ai e hiki i ka cloning virus ke hoʻolōʻihi i nā haʻawina e pili ana i nā maʻi viral?
• He aha nā pilikia ʻē aʻe o ka hana hou ʻana i nā maʻi maʻi i loko o ka lab?