Ntchito ya Microbe-engineering: Makampani tsopano atha kugula zamoyo zopangira

• Author:
• Dzina la wolemba

  Quantumrun Foresight
• December 21, 2022

Chidule cha chidziwitso

Synthetic biology imagwira ntchito yopanga ziwalo zolowa m'malo ndi zamoyo zosiyanasiyana. Kukonzekera kumeneku kwapangitsa kuti makampani a biotech ndi oyambitsa apeze tizilombo tating'onoting'ono tating'onoting'ono ngati ntchito, makamaka pakupanga mankhwala ndi kafukufuku wa matenda. Zotsatira zina zanthawi yayitali za ntchitoyi zitha kuphatikizirapo zinthu zamagetsi zamagetsi ndi ma organoid osiyanasiyana oyesa mankhwala.

Ntchito ya Microbe-engineering service

Akatswiri a zamoyo apeza kuti tizilombo toyambitsa matenda si tizilombo toyambitsa matenda komanso timathandiza pa thanzi la munthu. Ma "probiotics" awa - tizilombo tating'onoting'ono timene timakhala ndi thanzi labwino tikamadya mokwanira - makamaka mitundu ya mabakiteriya a lactic acid omwe amapezeka kale muzakudya zina. Chifukwa cha ukadaulo wotsatira wa DNA, tikuphunzira zambiri za tizilombo tomwe timatitcha kunyumba komanso momwe timafunikira pa thanzi lathu.

Asayansi amapanga tizilombo toyambitsa matenda, kupanga tizilombo tating'onoting'ono tating'onoting'ono tating'onoting'ono, ndikuyang'ana kusintha kwa mitundu yomwe ilipo. Kuti akwaniritse zatsopanozi, ofufuza amasintha ndikutsatira mfundo za biology yopanga. Mitundu yatsopano ya tizilombo tating'onoting'ono idzakhala yoposa zomwe zilipo panopa monga matanthauzo a probiotic pazakudya. M'malo mwake, makampani opanga mankhwala amatha kuwatenga ngati "mankhwala" kapena "mankhwala ochiritsira amoyo," malinga ndi kafukufuku wofalitsidwa mu Frontiers in Microbiology.

Tizilombo tambiri tomwe tapangidwa ndi majini tafufuzidwa kuti tipeze katemera wa antigen, koma ndi ochepa omwe adafika pakuyesa kwachipatala kwa anthu. Zina zomwe zitha kugwiritsidwa ntchito pazamankhwala opangidwa ndizomwe zimaphatikizira kuchiza matenda a autoimmune, kutupa, khansa, matenda, ndi zovuta za metabolic. Chifukwa cha phindu la majeremusi opangidwa ndi majini, makampani ambiri a sayansi ya sayansi akufufuza za thanzi komanso m'magulu osiyanasiyana, monga ulimi ndi sayansi ya zipangizo.

Zosokoneza

Mu 2021, oyambitsa biotechnology ku US Zymergen adalengeza zolinga zake zofulumizitsa chitukuko chazinthu zatsopano mu biopolymers ndi zida zina zamagawo amagetsi ndi chisamaliro cha ogula. Malinga ndi woyambitsa mnzake Zach Serber, pali kuyambiranso kwa sayansi chifukwa cha kuchuluka kwa mankhwala omwe amapezeka kudzera mu biology. Ndi ma biomolecules opitilira 75,000 omwe ali ndi Zymergen, pali kulumikizana pang'ono pakati pa zomwe zimapezeka m'chilengedwe ndi zomwe ziyenera kugulidwa kuchokera kumagwero azamalonda.

Kupereka koyamba kwa Zymergen mu 2021 kudapangitsa kuti akweze $500 miliyoni, kuyika mtengo wake pafupifupi $3 biliyoni. Kampaniyo ikukonzekera kukhazikitsa zatsopano kudzera mu biology yopanga zaka zisanu kapena zocheperapo pamtengo wakhumi wa mankhwala ndi zida zachikhalidwe. Malinga ndi kusungitsa kwake ku US Securities and Exchange Commission (SEC), nthawi yomwe akuyembekezeka kuyambitsa malonda ndi pafupifupi zaka zisanu, zomwe zimawononga USD $50 miliyoni.

Mbali ina ya kafukufuku wa majeremusi opangidwa ndi ma genetic ali mu danga la feteleza wa mankhwala. Mu 2022, asayansi adayesa kuti asinthe zoipitsazi ndi ma virus opangidwa ndi majini. Ofufuzawo adasintha mitundu ya mabakiteriya osinthika kuti akhazikitse mizu ya mbewu zampunga ndikubweretsa nayitrogeni wokhazikika kwa iwo. Atha kuchita izi popanda kuwononga posintha kuchuluka kwa ammonia mabakiteriya opangidwa. 

Gululi likusonyeza kuti, m'tsogolomu, ochita kafukufuku akhoza kupanga mabakiteriya makamaka kuti akwaniritse zosowa za mbewu. Zimenezi zingachepetse kutuluka kwa nayitrogeni ndi kutulutsa madzi m’thupi, njira imene imachitika pamene zinyalala za munthaka zimapita m’madzi. 

Zotsatira za ntchito za microbe-engineering

Zomwe zimakhudzidwa kwambiri ndi ntchito zopanga ma microbe zingaphatikizepo: 

• Makampani a biopharma omwe amagwirizana ndi makampani opanga zamankhwala kuti athandizire kukulitsa ndi kuyesa mankhwala.
• Makampani opanga mankhwala okhazikika omwe amasinthasintha magwiridwe antchito awo popanga kapena kuyika ndalama pazoyambira zopanga ma microbe-engineering kuti apange ma virus opangidwa kuti apange mankhwala osowa.
• Zoyambira zomwe zimayang'ana kwambiri pakukula kwazinthu zachilengedwe, monga zolimba, zosinthika kwambiri, zida zamagetsi zamagetsi.
• Kupita patsogolo kwaukadaulo wosintha ma gene ndikusintha ma gene kumapangitsa kuti pakhale kuchulukirachulukira kwa zida zopangidwa ndi majini, monga maloboti amoyo omwe amatha kudzikonza okha.
• Mgwirizano wambiri pakati pa mabungwe ofufuza ndi biopharma kuti apeze tizilombo toyambitsa matenda ndi katemera watsopano.
• Mitundu yosiyanasiyana ya ma organoid ndi ma body-in-a-chip prototypes omwe angagwiritsidwe ntchito pophunzira matenda osiyanasiyana ndi machiritso amtundu.

Mafunso oyenera kuwaganizira

• Mukuganiza kuti mainjiniya a microbe ngati ntchito angasinthe bwanji kafukufuku wamankhwala?
• Ndi zovuta zotani zomwe zingachitike pogwiritsa ntchito zida zopangidwa ndi chibadwa?