Futha isikhumba ukuze uthole ukusha: Ukuguqula izinqubo zokuxhunyelelwa zendabuko

• About the Author:
• Igama lomlobi

  I-Quantumrun Foresight
• July 28, 2022

Isifinyezo sokuqonda

Ubuchwepheshe bokuxhunyelelwa kwesikhumba obuthuthukile buguqula ukwelashwa kokusha. Lezi zindlela zokwelapha ezifuthwayo zinikeza ezinye izindlela ezisebenzayo zokuhlinzwa kwe-graft kwendabuko, ezikhuthaza ukuphulukiswa okusheshayo, ukuncishiswa kwezibazi, kanye nobuhlungu obuncane. Ngaphandle kokunakekelwa kokushiswa, lezi zindlela ezintsha zinamandla okwenza ukwelashwa kwentando yeningi, ukunciphisa izindleko zokunakekelwa kwezempilo, kanye nokulungisa kabusha ukuhlinzwa kwezimonyo.

Futha isikhumba ukuze uthole umongo wokusha

Izisulu zokusha kanzima zivame ukudinga ukuhlinzwa kwesikhumba ukuze kusheshiswe inqubo yokuphola nokunciphisa izibazi. Kuhilela ukuthatha isikhumba esingalimele kulowo ohlukunyeziwe bese usinamathisela ngokuhlinzwa enxebeni elishile ukuze silekelele ekupholekeni. Ngenhlanhla, kusetshenziswa ubuchwepheshe obusha ukuze kuthuthukiswe ukusebenza kahle kwale nqubo.     

Isistimu ye-RECELL ihilela ukuthatha i-graft encane ye-mesh yesikhumba esinempilo kumuntu oshile bese icwiliswa kusisombululo se-enzyme ukuze kwakhe ukumiswa kwamangqamuzana aphilayo angafuthwa emanxebeni ashisayo. I-graft yesikhumba elingana nekhadi lesikweletu ingasetshenziswa ukumboza ngempumelelo yonke into eshile ngale ndlela. Ngaphezu kwalokho, inqubo yokululama kubikwa ukuthi iyashesha, ayibuhlungu kangako, futhi ibhekana nethuba elincishisiwe lokutheleleka kanye nezibazi.
 
Esinye isimangaliso se-bioengineering yi-denovoSkin ye-CUTISS. Nakuba kungesona isifutho ngokunembile, sisebenza ngokufanayo ukunciphisa inani lokuxhunyelelwa kwesikhumba okunempilo okudingekayo. Kuthatha amaseli esikhumba angashisiwe, awaphindaphinde, futhi awahlanganise ne-hydrogel okuholela kusampula yesikhumba esiwugqinsi esingu-1mm sendawo engaphezulu ephindwe kayikhulu. I-denovoSkin ingenza ama-graft ambalwa ngesikhathi ngaphandle kokufaka okwenziwa ngesandla. Izivivinyo zesigaba III zomshini kulindeleke ukuthi ziphele ngo-2023.   

Umthelela ophazamisayo   

Lezi zinqubo zinamandla okwenza izinketho zokwelapha zentando yeningi, zizenze zifinyeleleke kalula kubantu abaningi, kuhlanganisa nabantu abasezindaweni zempi lapho izinsiza zezokwelapha zingakhawulelwa. Ngokuphawulekayo, ukungenelela okuncane okwenziwa ngesandla okudingekayo kulobu buchwepheshe, ngaphandle kwezimo zokukhishwa kwesikhumba ngokuhlinzwa, kuyinzuzo enkulu, ukuqinisekisa ukuthi ngisho nasezilungiselelweni ezivinjelwa izinsiza, iziguli zingazuza kulezi zindlela zokwelapha.

Uma sibheka phambili, amandla okunciphisa izinhlungu kanye nokunciphisa ukutheleleka kwalezi zindlela zobuchwepheshe kulindeleke ukuthi abe nomthelela omkhulu. Iziguli ezishisiwe zivame ukubekezelela ubuhlungu obukhulu phakathi nenqubo yazo yokululama, kodwa izinto ezintsha ezifana nesikhumba sesifutho zingakuqeda ngokuphawulekayo lokhu kuhlupheka. Ngaphezu kwalokho, ngokunciphisa ubungozi bokutheleleka, lezi zindlela zokwelapha zinganciphisa isidingo sokuhlala isikhathi eside esibhedlela nokunakekelwa okubanzi kokulandelela, kunciphise izindleko zokunakekelwa kwezempilo kanye nezinsiza.

Ngaphezu kwalokho, imiphumela yesikhathi eside idlulela emkhakheni wokuhlinzwa kwezimonyo. Njengoba lobu buchwepheshe buqhubeka buthuthuka, bungasetshenziselwa izinjongo zobuhle, kwenze ukuhlinzwa kwezimonyo kungabizi kakhulu futhi kuphumelele. Lokhu kuthuthukiswa kunganika abantu amandla okuthuthukisa ukubukeka kwabo ngokuzethemba okukhulu kanye nezingozi ezimbalwa, ekugcineni balolonge kabusha imboni yezimonyo.

Imithelela yezinhlelo ezintsha zokuxhunyelelwa kwesikhumba

Imithelela ebanzi yobuchwepheshe besikhumba sesifutho ingabandakanya:

• Ukuthuthukiswa kwezindlela zokwelapha ezintsha zezifo zesikhumba ezingavamile.
• Ukuthuthukiswa kwezindlela zokwelapha ezixubile ezihlanganisa izindlela ezindala nezintsha ukusiza izinqubo zokuphulukisa. 
• Ukuthuthukiswa kwamasu amasha okuvuselela ubuso nezitho, ikakhulukazi kwabesifazane abayizisulu zokuhlaselwa nge-asidi.
• Ukwelashwa okusheshayo futhi yingakho ukuphepha okukhulu kunikezwa izicishamlilo nezinye izisebenzi eziphuthumayo.
• Ukuthuthukiswa kwezinketho ezintsha zokuhlinza izimonyo ezigulini ezinezimpawu zokuzalwa ezinkulu kakhulu noma ukukhubazeka kwesikhumba. 
• Izinqubo ezintsha zezimonyo ezizogcina zivumele abantu abanempilo enhle ukuthi bakhethe ukushintsha izingxenye noma ingxenye enkulu yesikhumba sabo ngesikhumba sombala ohlukile noma ithoni. Le nketho ingase ibe nesithakazelo ikakhulukazi ezigulini esezikhulile ezifuna ukushintsha isikhumba sazo esidala noma esishwabene ngesikhumba esincane, esiqinile.

Imibuzo okufanele icatshangelwe

• Ucabanga ukuthi ubuchwepheshe obunjalo bungathuthwa futhi busetshenziswe ngokushesha kangakanani ezindaweni zempi?
• Ngabe ucabanga ukuthi izindlela zokwelapha zizoba ngokwentando yeningi njengoba kuthenjisiwe?