'Bio-Spleen': Kupambana pochiza matenda obwera ndi magazi

Chithandizo cha matenda ambiri obwera ndi magazi chafika pachimake chifukwa cha chilengezo chaposachedwa cha chipangizo chomwe chimatha kuyeretsa magazi ku tizilombo toyambitsa matenda. 

Asayansi pa Wyss Institute for Biologically Inspired Engineering ku Boston apanga “kachipangizo kochotsa magazi kochotsa magazi kochizira matenda a sepsis.” M'mawu a layman, chipangizochi ndi ndulu yopangidwa mwaluso yomwe, ngati palibe yomwe imagwira ntchito bwino, imatha kuyeretsa magazi ku zonyansa monga E-coli ndi mabakiteriya ena omwe amayambitsa matenda monga Ebola.

Matenda opatsirana m'magazi ndi ovuta kwambiri kuchiza, ndipo ngati chithandizo chamankhwala chikuchedwa kwambiri, chingayambitse sepsis, chomwe chingathe kupha chitetezo cha mthupi. Kuposa theka la nthawi, madokotala samatha kudziwa chomwe chinayambitsa sepsis poyamba, zomwe nthawi zambiri zimawatsogolera kuti apereke mankhwala opha tizilombo toyambitsa matenda omwe amapha mabakiteriya ambiri ndipo nthawi zina amapanga zotsatira zosafunika. Chinthu china chofunika kuchiganizira panthawi yonseyi ndi kupanga mabakiteriya opambana kwambiri omwe sagonjetsedwa ndi ma antibiotic.

Momwe ndulu yapamwambayi imagwirira ntchito

Poganizira izi, katswiri wa bioengineer Donald Ingber ndi gulu lake anayamba kupanga ndulu yochita kupanga yomwe imatha kusefa magazi pogwiritsa ntchito mapuloteni ndi maginito. Makamaka, chipangizochi chimagwiritsa ntchito mannose-binding lectin (MBL), puloteni yamunthu yomwe imamangiriza ku mamolekyu a shuga pamwamba pa mabakiteriya opitilira 90, ma virus ndi bowa, komanso poizoni wotulutsidwa ndi mabakiteriya akufa omwe amayambitsa sepsis m'magazi. malo oyamba.

Powonjezera MBL ku maginito nano-mikanda ndikudutsa magazi kudzera mu chipangizocho, tizilombo toyambitsa matenda m'magazi timamanga mikanda. A maginito ndiye amakoka mikanda ndi constituent mabakiteriya awo m'magazi, amene tsopano woyera ndi wokhoza kubwezeretsedwanso mwa wodwalayo.

Ingber ndi gulu lake adayesa chipangizocho pa makoswe omwe ali ndi kachilomboka, ndipo atapeza kuti 89% ya makoswe omwe ali ndi kachilombo akadali ndi moyo pakutha kwamankhwala, adadabwa ngati chipangizocho chingathe kuthana ndi kuchuluka kwa magazi a munthu wamkulu (pafupifupi malita asanu). Podutsa magazi a anthu omwe ali ndi kachilombo kofanana ndi chipangizocho pa 1L / ola, adapeza kuti chipangizocho chinachotsa tizilombo toyambitsa matenda ambiri mkati mwa maola asanu.

Mabakiteriya ambiri atachotsedwa m'magazi a wodwalayo, chitetezo chawo cha mthupi chimatha kuthana ndi zotsalira zawo zofooka. Ingber akuyembekeza kuti chipangizochi chidzatha kuchiza matenda akuluakulu, monga HIV ndi Ebola, kumene chinsinsi cha kupulumuka ndi chithandizo chogwira ntchito ndi kuchepetsa mlingo wa pathogenic wa magazi a wodwalayo asanaukire matendawa ndi mankhwala amphamvu.