Kufunika kwa malo mu (T-cell receptor) malo enieni

T-maselo akhala akudziwika kwa nthawi yayitali ngati linchpin ya chitetezo chamthupi. Kuzindikirika kwa zinthu zomwe zingakhale zovulaza (monga tizilombo toyambitsa matenda kapena ma cell a khansa) zimatengera kutsegulira kwa ma receptor omwe amwazikana pamtunda wa T-cell. Mwanjira ina: "Chizindikiro cha chitetezo chamthupi chosinthika ndikutha kwa ma T-cell kuzindikira ma antigen. "

Zowopsa zikadziwika, zizindikiro za biochemical zimatumizidwa kuti ziwukire oukirawo. Kukhala ndi T-maselo okhala ndi zolandilira pamwamba nthawi zambiri kumaganiziridwa kuti ndiye njira yabwino yoyankhira chitetezo chamthupi. 

Kafukufuku waposachedwa paukadaulo woyerekeza wa maselo akutsutsa malingaliro awa okhudza T-cell ndi mphamvu yake. Malinga ndi kafukufukuyu, kukhala ndi ma T-cell okhala ndi ma receptor oyambitsa sikungakhale kofunikira ngati momwe ndi kumene ma receptors amayikidwa. 

Ofufuza ku Yunivesite ya South Wales awonetsa kuti kutsegulira kwa ma T-cell receptors kumatha kukhala kogwirizana ndi kugawa kwawo. Ndiko kuti: ma receptor akamangika kwambiri, m'pamenenso maselo amakhala ndi mwayi wozindikira antigen ndikuyika chitetezo. 

Kafukufuku akuwonetsa kuti ngati zolandilira pamwamba sizikhala munjira yoyenera kutsekera ku antigen, kuchuluka kwa ma T-cell omwe alipo sikungapange kusiyana kwenikweni. Mosiyana ndi izi, bola ngati ma receptor ali pamalo apamwamba, amatha kukhala ochita bwino pantchito zawo zomangirira.

Kuyika kwa T-cell ngati chitukuko chachipatala

Kudziwa kumeneku kungathandize kuti pakhale chitukuko chachipatala m'tsogolomu. Asayansi akuyembekeza kugwiritsa ntchito nanotechnology kuti akonzenso zolandilira pamodzi ndi ma T-cell kuti akhale magulu ogwira mtima kwambiri. Sikuti magwiridwe antchito a ma receptor angakwaniritsidwe ndi njirayi, palinso kuthekera kolemba ma T-maselo ambiri mu dziwe lachitetezo. Izi zitha kuchitika poyambitsanso zolandilira m'maselo "otopa". 

Kufufuza njira zatsopano zowonjezera chitetezo cha thupi la munthu kungayambitse mankhwala otsogolera, amphamvu omwe alibe zotsatirapo zomwe nthawi zina zimabweretsedwa ndi maantibayotiki kapena mankhwala oletsa khansa. Kusintha komwe kuli ma T-cell receptors kungakhale gawo loyamba pakukulitsa chitetezo chachilengedwechi.