COVID-19 organoids: Xubnaha shaybaadhka lagu sameeyay ayaa fududeynaya dadaallada cilmi-baarista

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  Quantumrun Aragtida Saadaasha
• November 15, 2022

Soo koobid aragti

Organoids, xubnaha yaryar ee laga soo qaatay unugyada asliga ah, ayaa wax ka beddelaya fahamkayaga COVID-19 iyaga oo si dhow uga dayanaya jawaabta unugyada aadanaha. Waxay bixiyaan fikrado qiimo leh oo ku saabsan saameynta uu fayrasku ku leeyahay xubnaha kala duwan, iyagoo gacan ka geysanaya horumarinta daawaynta iyo tallaalada la beegsanayo. Saamaynta cilmi-baadhista organoid waxay ka sii dheer tahay shaybaadhka, taasoo suurtogal ah inay saamayn ku yeelato manhajka waxbarashada, siyaasadaha sharciyaynta, iyo daawaynta gaarka ah ee caafimaadka.

COVID-19 organoids macnaha guud

Isticmaalka organoids ee cilmi baarista COVID-19 ayaa awood u siisay horumarinta degdega ah ee xeeladaha wax looga qabanayo cudurka, oo ay ku jiraan tallaalada iyo daweynta. Organoids waxay ka tarjumaysaa physiology bini'aadamka si ka dhow hababka kale ee moodooyinka waxayna si guul leh u muujiyeen saameynta fayraska ee xubnaha kala duwan iyo sidoo kale musharaxiinta daroogada ee suurtagalka ah ee saameeya cudurka. Waa xubno aad u yar, oo iskood isu abaabulay oo laga soo saaray unugyada asliga ah ee qaangaarka ah kuwaas oo soo bandhigaya matalaad sax ah oo ka badan unugyada nool marka loo eego khadadka unugyada caadiga ah ama moodooyinka xayawaanka. 

Ballaarinta cilmi-baarista organoid-ka iyo tijaabinta ayaa loo oggolaaday goobo cilmi-baaris oo kala duwan si loo sii baaro, oo ay ku jiraan qaabeynta cudurrada, isdhexgalka martida-pathogen, iyo bangiyada noolaha ee organoid-ka bukaan-socodka. Tusaale ahaan, 2022, cilmi-baarayaashu waxay codsadeen noolaha sambabada ee bini'aadamka si ay u daraaseeyaan cudurrada neef-mareenka sida fayraska syncytial breath (RSV) iyo hargabka. Cilmi-baadhayaashu waxay ogaadeen in labadaba fayrasyadu ay waxyeeleeyaan koritaanka unugyada sambabada.

Natiijooyinkani waxay bixiyaan aragtiyo muhiim ah oo ku saabsan hab-dhaqanka cudurrada neef-mareenka. Gaar ahaan, daraasaddu waxay muujisay in Organoids loo isticmaali karo in lagu daydo cudurrada bini'aadamka ee deegaanka la xakameeyey, kuwaas oo saynisyahannadu ay u isticmaali karaan baaritaanka daroogada iyo ujeedooyin kale oo cilmi baaris ah.

Saamaynta qaska

Dhowr organoids ayaa loo isticmaalay in lagu barto saamaynta kala duwan ee coronavirus. Organoid-ka sambabada, gaar ahaan, ayaa ahaa barta ugu muhiimsan ee tijaabooyinkan, maadaama xubintaasi tahay tan ugu badan ee ay saamaysay. Daraasaduhu waxay daboolayaan mawduucyo kala duwan, oo ay ku jiraan sida: 

• Fayrasku wuu fidaa, 
• ninkii martida ahaa ayaa ku jawaabay, 
• kala duwanaanshiyaha hidda-socodka ayaa saameeya u nuglaanta fayraska, iyo 
• Daawooyinka cusub ee suurtagalka ah ayaa laga yaabaa inay la falgalaan organoid-ka. 

Taas bedelkeeda, Organoids-ka maskaxda ayaa ka caawiyay saynisyahannada inay go'aamiyaan sida dadku u lumiyeen dareenkooda urta ka dib caabuqa. Natiijooyinku waxay soo jeedinayaan in SARS-CoV-2 laga yaabo inuu yahay fayras neurotropic ah (fayras weerara habka dareemayaasha ugu horrayn). Saynis yahanadu waxay sidoo kale ka heleen fayraska RNA muunada maskaxda ee bukaanada cudurka qaba. Daraasado lagu sameeyay organoids-ka mindhicirka ayaa shaaca ka qaaday sida fayrasku u kiciyay calaamadaha caloosha sida shuban, lallabbo, matag, anorexia, iyo calool xanuun. Unugyada kale ee ka mid ah daraasadaha COVID waa xididdada dhiigga, kelyaha, beerka, iyo muunadaha indhaha.

Si kastaba ha ahaatee, nidaamka organoid ee bini'aadamka ayaa leh xoogaa faa'iido darro ah. Dhaqamada Organoidku waa qaali in la maareeyo wayna adagtahay in la xakameeyo. Waxa kale oo ay ka maqan yihiin dhinacyo badan oo nafsiyeed oo moodooyinka nool. Intaa waxaa dheer, jawaabaha ka hortagga fayraska iyo tropism-ka gacanta ayaa inta badan ku kala duwan daraasado kala duwan. Mid ka mid ah sababaha suurtogalka ah ee iswaafaq la'aanta ayaa noqon karta la'aanta borotokoolka caadiga ah ee shaybaarada kale. Halbeeg la'aanta ayaa laga yaabaa inay saameyn ku yeelato heerka korriinka noolaha iyo halabuurka gacanta. 

Saamaynta COVID-19 organoids

Saamaynta ballaadhan ee COVID-19 organoids waxa ka mid noqon kara: 

• Shirkadaha dawooyinka ayaa si sii kordheysa u isticmaalaya organoids si ay u horumariyaan tallaalo cusub oo ay u qabtaan tijaabooyinka bini'aadamka si dhakhso leh.
• Saynis yahano badan ayaa ku tababara adeegsiga Organoids, oo ay ku jiraan sida loo qaabeeyo oo loola socdo marka ay ka jawaabayaan dawooyinka tijaabada ah ee kala duwan.
• Organoids loo isticmaalo barnaamijyada tababarka ee cilmi-baarayaal caafimaad iyo saynisyahano kala duwan.
• Abuuritaanka organoids-ka isku xiran ee u eg bayoloji aadanaha, isbeddelkan ayaa ka caawin kara cilmi-baarayaasha inay sameeyaan tijaabooyin sax ah oo dheeri ah oo ku saabsan saameynta COVID-19 iyo fayrasyada kale.
• Organoids loo isticmaalo in lagu barto heerka caabuqa ka dib, oo ay ku jiraan saamaynta muddada-dheer ee sambabada, wadnaha, iyo maskaxda.
• Isbitaalada ku jira farsamooyinka ku salaysan organoid si loo shakhsiyeeyo qorshooyinka daawaynta bukaanka, kor u qaadida soo kabashada iyo yaraynta waxyeelada.
• Machadyada waxbarashada oo wax ka beddelaya manaahijta si loogu daro tignoolajiyada organoid, qalabaynta xirfadlayaasha daryeelka caafimaadka mustaqbalka ee leh xirfado horumarsan.
• Hay'adaha sharciyeynta oo habaynaya tilmaamaha si ay u kormeeraan cilmi-baarista organoid iyo codsiga, hubinta dhaqamada anshaxa iyo badbaadada leh ee horumarinta caafimaadka.

Su'aalaha la tixgeliyo

• Sidee kale organoids-ka ayaa ka caawin kara saynisyahannada inay wax badan ka ogaadaan cudurrada faafa ee kala duwan?
• Maxay noqon karaan caqabadaha kale ee suurtagalka ah ee tijaabinta organoids?