I-"Mussel Glue" ivala amanxeba ngaphandle kokuthungwa noma ukwesaba

Ngo-2015, into ethathwe imbaza yansuku zonke iboniswe ukusiza ukuvikela ukwakheka kwesibazi. Kakade lokhu "i-mussel glue" isetshenziswe  ngempumelelo ezinhlelweni eziningi zomtholampilo, okuholela ekwakhiweni kwenguqulo ethuthukisiwe ethembisa imiphumela engcono nakakhulu. 

Ukuvimbela izibazi ukuba zingaveli kuhlanganisa ukuqonda ukuthi amandla ahlukahlukene asebenzisana kanjani ukukhiqiza isibazi  esibonakalayo. Ukwakheka kwe-Collagen kanye nokuqina komshini kukhonjwa njengezici ezimbili ezixhumene ezithonya ukubonakala kokugcina kwanoma yisiphi isibazi.  

I-Collagen ingumdlali obalulekile enqubweni yokuphola kwesilonda. Itholakala kuwo wonke umzimba wethu, le phrotheni ihlelwa ngokwakheka kwe-weave ukunikeza amandla kanye nesimo esikhumbeni nezicubu ezingaphansi. Uma kwenzeka ukulimala, umzimba uzama ukwakha kabusha le lathisi ngokuyenga amaseli ukuthi akhiphe i-collagen. Uma kune-collagen eningi efakwe phakathi nenqubo yokuphola, isibazi esingabukeki singase sivele. 

Isikhumba sethu ngokuyisisekelo siyisitho esinwebekayo esimboza wonke umzimba wethu, ngaphansi kokuphusha nokudonsa njalo ngesikhathi sokunyakaza. Enxebeni elivulekile, ukungezwani kuvame ukudonsa noma ukugcina imiphetho ihlukene, futhi umzimba ukhiqiza inani elikhulu le-collagen ukuvala igebe. Lesi yisizathu esenza ukuthi izilonda ziphole—futhi zibukeke—zingcono kakhulu lapho lezi ziphetho zibambisene ndawonye, ​​ngokugcina la mandla akhubazayo ekude. Nakuba ngokwesiko lokhu kwenziwa kusetshenziswa imithungo noma ama-staples, iglues noma okokunamathisela kuye kwasetshenziswa njengezinye izindlela ezingalimazi kangako isikhumba noma izicubu. 

Abacwaningi kudala beqonda ukuthi ama-mollusk asolwandle akhipha into ewagcina ebambelele ngisho nasezindaweni ezinyakazayo—empeleni, ingcina engangeni manzi. Isici esiqinile  sokunamathisela esimweni esiwuketshezi siwusizo ikakhulukazi lapho usebenza namanxeba ngenxa yezindawo ezifanayo ngenxa yokusebenzisana okungapheli kwezingxenye zamaselula noketshezi phakathi nenqubo yokuphola.  

Ukuthatha lesi sinyathelo esisodwa phambili, isihloko esivela ku-New Scientist ibika ukuthi ososayensi baseNingizimu Korea bahlose ukuqinisa ukwakheka kwabo kwangaphambilini ngokukuhlanganisa ne-chemical mediator enganciphisa ukwakheka kwezibazi. 

I-Decorin iphrotheni etholakala emzimbeni womuntu enendima eyinkimbinkimbi enqubweni yokuphulukiswa kwesilonda. I-Decorin ilungisa kabusha ukubonakala kokugcina kwesibazi ngokusebenzisana nama-collagen fibrils. Izibazi nama-keloid atholakala entula ku-decorin, okungase kubangele ukungalawulwa kwe-collagen. Ezivivinyweni ezilawulwayo, i-decorin iboniswe ukuthi ivimbela ukwakheka kwezibazi, ivumela izinqubo zokuphulukisa ‘ezivamile’ ziqhubeke. 

Ngokuhlanganisa i-analog yokwenziwa ye-decorin kuglue yabo eyakhiwe ngaphambilini, abacwaningi banethemba lokuqhubeka bavimbele ukwakheka kwezibazi ngokungagcini ngokwehlisa i-mechanical tension kodwa ngokulawula ukufakwa kwe-collagen eningi. Ucwaningo lokuqala lwaselabhorethri lubonise isithembiso mayelana nalokhu, futhi uma kufakazelwa ukuthi lusebenza kahle, le nguqulo ethuthukisiwe yeglue ngolunye usuku ingangena esikhundleni senaliti yokuhlinza noma i-stapler, ngenzuzo eyengeziwe yokungabi khona kwesibazi esibonakalayo.