Nano-tshuaj kho mob yuav tsum kho cov mob ntev

Txawm hais tias nws yog cov plaub hau poob, xeev siab, lossis cov tshuaj uas tsis muaj qhov kawg, txhua tus neeg uas tau ntsib kev mob qog noj ntshav paub tias kev kho mob tuaj yeem ua rau muaj kev ntxhov siab. Cov tshuaj chemotherapy ib txwm muaj peev xwm los tawm tsam cov hlwb noj qab haus huv ntxiv rau cov teeb meem malignant, uas ua rau muaj kev txom nyem li no. Tab sis yuav ua li cas yog tias peb tuaj yeem kho mob qog noj ntshav yam tsis muaj kev cuam tshuam dab tsi? Yuav ua li cas yog tias peb tuaj yeem tsom cov tshuaj ntawm cov hlwb ua txhaum nkaus xwb thiab tso tawm ncaj qha thaum peb xav tau?

Adah Almutairi, tus thawj coj ntawm Center for Excellence hauv Nanomedicine thiab Engineering ntawm University of California, San Diego (UCSD), tau tsim cov thev naus laus zis uas cuam tshuam nrog lub teeb-activated nanoparticles uas tuaj yeem ua tau li ntawd. Siv cov teeb meem ntawm qhov ntsuas ntawm 100nm, Almutairi thiab nws pab neeg tshawb fawb tau tso cov tshuaj molecules rau hauv cov pob me me uas nws hu ua nanospheres. Thaum muab tshuaj rau kev kho mob, cov tshuaj tseem nyob hauv lawv cov pob, tsis tuaj yeem ua rau lawv raug kev puas tsuaj rau cov hlwb dawb huv, tsis xav txog. Thaum raug rau lub teeb ze-infrared, txawm li cas los xij, nanospheres tawg, tso cov ntsiab lus hauv. Cov kev cuam tshuam yog crystal ntshiab: yog tias peb muaj peev xwm tswj tau raws nraim thaum twg thiab qhov twg cov tshuaj xav tau, tsis yog tsuas yog tuaj yeem siv tshuaj nce ntxiv, cov kev mob tshwm sim tuaj yeem txo qis.

Almutairi tau hais tias "Peb xav kom cov txheej txheem no ua haujlwm tau zoo, txhawm rau txo qis cov teebmeem ntawm cov tshuaj tiv thaiv," Almutairi tau hais.

Tab sis Almutairi qhov kev tsim tawm tsis yog qhov tshwj xeeb hauv txoj cai. Qhov tseeb, lub hom phiaj xa tshuaj tau nyob ntawm qhov ua ntej ntawm kev tshawb fawb hauv thaj chaw loj hlob ntawm nanomedicine rau qee lub sijhawm. Cov kws tshawb fawb thawj zaug sim xa cov tshuaj los ntawm liposomes, cov hlab ntsha kheej kheej uas ib txwm sib sau ua ke vim muaj cov khoom ntawm nws cov phospholipids.

Xiaosong Wang, tus xibfwb ntawm nanotechnology ntawm University of Waterloo hais tias "Qhov teeb meem nrog liposomes yog vim tias lawv muaj biocompatible, lawv tsis ruaj khov heev," "Lawv sib cais yooj yim, yog li lawv tsis muaj txiaj ntsig zoo rau kev xa tshuaj."

Wang's lab, uas nyob hauv Waterloo Lub Tsev Haujlwm ntawm Nanotechnology, ua kev tshawb fawb ntawm tus kheej ntawm cov hlau uas muaj cov copolymers - zoo ib yam li cov liposomes, tab sis ntau ruaj khov thiab ntau yam sib txawv. Magnetism, redox, thiab fluorescence yog tab sis ob peb ntawm cov khoom ntxim nyiam uas muaj nyob rau hauv cov hlau uas muaj kev zoo siab rau kev siv tshuaj thiab ntau dua.

"Muaj ntau yam uas koj yuav tsum xav txog thaum siv cov hlau uas muaj cov polymers rau kev xa tshuaj. Qhov teeb meem loj tshaj plaws yog toxicity [los yog nws tuaj yeem ua mob rau peb lub cev li cas]. Tom qab ntawd muaj biodegradability, "hais tias Wang.

Qhov ntawd yog qhov uas Almutairi tus qauv yuav tau ntaus kub. Tsis tsuas yog nws nanospheres "ruaj khov li pob zeb", tab sis lawv kuj muaj kev nyab xeeb zoo kawg nkaus. Raws li nws, nanospheres tuaj yeem "nyob twj ywm rau ib xyoos ua ntej kev nyab xeeb," raws li tau pom hauv kev sim tsiaj nrog nas. Qhov tseem ceeb ntawm qhov ntawd yog monumental, qhia tias tsis muaj tshuaj lom yuav yog thawj kauj ruam hauv kev tau txais nws qhov kev tsim khoom hauv khw.