Ts'ebeletso ea boenjineri ba Microbe: Likhamphani joale li ka reka lintho tsa maiketsetso

• Author:
• Lebitso la sengoli

  Quantumrun Ponelopele
• December 21, 2022

Kakaretso ea kutloisiso

Synthetic biology e sebetsana le ho theha litho tse ncha le mefuta e ikhethang ea lintho tse phelang. Boqapi bona bo lebisitse ho lifeme tsa biotech le tse qalang tse fanang ka tšibollo ea likokoana-hloko tse ncha e le ts'ebeletso, haholo bakeng sa nts'etsopele ea lithethefatsi le lipatlisiso tsa mafu. Litlamorao tse ling tsa nako e telele tsa ts'ebeletso ena li ka kenyelletsa likarolo tsa biodegradable bakeng sa lisebelisoa tsa elektroniki le li-organoid tse fapaneng bakeng sa tlhahlobo ea lithethefatsi.

Boemo ba tšebeletso ea boenjiniere ba Microbe

Litsebi tsa baeloji li sibolotse hore likokoana-hloko tse ling hase feela lintho tse ka bang kotsi empa li boetse li molemo bophelong ba batho. "Li-probiotic" tsena - li-microorganisms tse phelang tse ntlafatsang bophelo ba rona ha li jeoa ka mokhoa o lekaneng-ke haholo mefuta ea libaktheria tsa lactic acid tse seng li le teng lijong tse itseng. Ka lebaka la theknoloji ea tatellano ea DNA ea moloko o latelang, re ntse re ithuta haholoanyane ka likokoana-hloko tse re bitsang hae—le hore na li bohlokoa hakae bophelong ba rona.

Bo-rasaense ke li-microbes tsa boenjiniere bakeng sa kalafo, ba theha mefuta e mecha ea likokoana-hloko, 'me ba shebane le ntlafatso ea mefuta e teng. Ho fihlela mekhoa ena e mecha, bafuputsi ba fetola le ho latela melao-motheo ea baeloji ea maiketsetso. Mofuta o mocha oa likokoana-hloko o tla feta seo hajoale se leng teng e le tlhaloso ea probiotic bakeng sa ts'ebeliso ea lijo. Sebakeng seo, indasteri ea meriana e ka li nka e le "litlhare tsa meriana" kapa "lihlahisoa tsa biotherapeutic tse phelang," ho latela lipatlisiso tse phatlalalitsoeng ho Frontiers in Microbiology.

Likokoana-hloko tse ngata tse entsoeng ka liphatsa tsa lefutso li 'nile tsa hlahlojoa bakeng sa phepelo ea antigen ea ente, empa ke tse fokolang tse fihletseng liteko tsa batho. Lisebelisoa tse ling tse ka sebelisoang bakeng sa likokoana-hloko tse entsoeng li kenyelletsa ho phekola mafu a autoimmune, ho ruruha, mofetše, tšoaetso le mathata a metabolism. Ka lebaka la molemo oa likokoana-hloko tse entsoeng ka liphatsa tsa lefutso, lifeme tse ngata tsa theknoloji ea baeloji li ntse li li hlahloba ka nģ'ane ho bophelo bo botle le likarolong tse sa tšoaneng, tse kang tsa temo le saense ea thepa.

Tšusumetso e senyang

Ka 2021, setsi sa US se thehiloeng ho biotechnology Zymergen e phatlalalitse merero ea eona ea ho potlakisa nts'etsopele ea lihlahisoa tse ncha ho li-biopolymers le lisebelisoa tse ling bakeng sa likarolo tsa elektroniki le tsa tlhokomelo ea bareki. Ho ea ka mothehi-'moho le eena Zach Serber, ho na le tsosoloso ea saense ka lebaka la bongata ba lik'hemik'hale tse fumanehang ka baeloji. Ka li-biomolecule tse fetang 75,000 tse fumanehang ho Zymergen, ho na le kamano e nyane lipakeng tsa se ka fumanoang tlholehong le se hlokang ho rekoa mehloling ea khoebo.

Nyehelo ea pele ea sechaba ea Zymergen ka 2021 e ile ea e lumella ho bokella lidolara tse limilione tse 500, e beha boleng ba eona ho hoo e ka bang $3 bilione. Khampani e rera ho hlahisa lihlahisoa tse ncha ka baeloji ea maiketsetso ka lilemo tse hlano kapa ka tlase ho karolo ea leshome ea litšenyehelo tsa lik'hemik'hale tsa setso le thepa. Ho latela kopo ea eona ho US Securities and Exchange Commission (SEC), nako e lekantsoeng ea ho qala sehlahisoa e ka ba lilemo tse hlano, e bitsa USD $50 milione.

Karolo e 'ngoe ea lipatlisiso bakeng sa likokoana-hloko tse entsoeng ka liphatsa tsa lefutso ke sebakeng sa menontsha ea lik'hemik'hale. Ka 2022, bo-rasaense ba ile ba etsa liteko tsa ho nkela lintho tse silafatsang sebaka ka likokoana-hloko tse entsoeng ka liphatsa tsa lefutso. Bafuputsi ba ile ba fetola mefuta ea libaktheria tse feto-fetohang hore li koale metso ea limela tsa raese le ho fana ka naetrojene ho tsona. Ba ne ba ka etsa joalo ntle le tšenyo ea letho ka ho lekanya tekanyo ea ammonia eo baktheria e e hlahisang. 

Sehlopha se fana ka maikutlo a hore, nakong e tlang, bafuputsi ba ka etsa libaktheria ka ho khetheha ho finyella litlhoko tsa lijalo. Khatelo-pele ena e ne e tla fokotsa ho phalla ha naetrojene le eutrophication, e leng mokhoa o etsahalang ha litšila tsa lik'hemik'hale tse tsoang mobung li hoholeha ho kena metsing. 

Liphello tsa lits'ebeletso tsa boenjiniere ba microbe

Litlamorao tse pharalletseng tsa lits'ebeletso tsa boenjiniere ba microbe li ka kenyelletsa: 

• Lifeme tsa Biopharma tse sebelisanang le lik'hamphani tsa biotech ho potlakisa nts'etsopele ea lithethefatsi le liteko.
• Lik'hamphani tse thehiloeng indastering ea lik'hemik'hale tse fapanyetsanang ts'ebetso ea tsona ka ho theha kapa ho tsetela ho tse qalang tsa boenjiniere ba likokoana-hloko ho theha likokoana-hloko tse entsoeng ho hlahisa metsoako ea lik'hemik'hale tse sa tloaelehang.
• Lits'oants'o tse shebaneng le nts'etsopele ea lisebelisoa tsa biomedical, joalo ka tse tiileng, tse tenyetsehang haholoanyane, likarolo tsa biodegradable bakeng sa lisebelisoa tsa elektroniki.
• Tsoelo-pele ea theknoloji ea ho hlophisa liphatsa tsa lefutso le tatellano ea liphatsa tsa lefutso e hlahisang ts'ebeliso e pharalletseng ea likarolo tse entsoeng ka liphatsa tsa lefutso, joalo ka liroboto tse phelang tse khonang ho itokisa.
• Tšebelisano e eketsehileng lipakeng tsa litsi tsa lipatlisiso le biopharma ho sibolla likokoana-hloko le liente tse ncha.
• Li-organoid tse fapaneng le li-prototypes tsa 'mele-in-a-chip tse ka sebelisoang ho ithuta mafu a fapaneng le liphekolo tsa lefutso.

Lipotso tse lokelang ho nahanoa

• U nahana hore boenjiniere ba microbe e le tšebeletso bo tla fetola lipatlisiso tsa bongaka joang?
• Liphephetso tse ka bang teng tsa ho sebelisa thepa e entsoeng ka liphatsa tsa lefutso ke life?