'Bio-Spleen': Impumelelo ekwelapheni amagciwane atholakala egazini

Ukwelashwa kwezifo eziningi ezitholakala egazini kuye kwafinyelela inqubekelaphambili njengoba kusanda kuvela isimemezelo somshini okwazi ukuhlanza igazi amagciwane ezifo. 

Ososayensi e-Wyss Institute for Biologically Inspired Engineering eBoston baye benza “ithuluzi lokuhlanza igazi elingaphezu komzimba elisetshenziselwa ukwelapha i-sepsis.” Ngokwemibandela ye-layman, idivayisi iwubende obunjiniyela okuthi, uma bungekho obuvamile obusebenza, bukwazi ukuhlanza igazi ekungcoleni okufana ne-E-coli namanye amagciwane angaphambili abangela izifo ezifana ne-Ebola.

Izifo ezitholakala egazini ziyaziwa ukuthi zinzima kakhulu ukwelapha, futhi uma ukungenelela kwezokwelapha kuhamba kancane, kungabangela i-sepsis, impendulo engase ibe yingozi yokuzivikela komzimba. Isikhathi esingaphezu kwengxenye yesikhathi, odokotela abakwazi ukuhlonza kahle ukuthi yini ebangele i-sepsis kwasekuqaleni, okuvame ukuholela ekunikezeni imithi elwa namagciwane ebulala amabhaktheriya amaningi futhi ngezinye izikhathi ikhiqize imiphumela emibi engathandeki. Okunye okucatshangelwayo okubalulekile kuyo yonke le nqubo yokwelapha ukwakheka kwamabhaktheriya aqine kakhulu angakwazi ukumelana nokwelashwa ngama-antibiotic.

Isebenza kanjani le spleen enkulu

Enalokhu engqondweni, unjiniyela wezinto eziphilayo uDonald Ingber nethimba lakhe baqala ukwakha ubende bokwenziwa olukwazi ukuhlunga igazi ngokusebenzisa amaprotheni nozibuthe. Ngokucacile, idivayisi isebenzisa i-mannose-binding lectin (MBL) eguquliwe, iphrotheni yomuntu ebophezela kuma-molecule kashukela ebusweni bamagciwane angaphezu kwama-90, amagciwane, nesikhunta, kanye nobuthi obukhishwe amagciwane afile abangela i-sepsis endaweni. indawo yokuqala.

Ngokungeza i-MBL kubuhlalu obuzibuthe be-nano kanye nokudlulisa igazi ngomshini, amagciwane asegazini abopha ubuhlalu. Uzibuthe ube esekhipha ubuhlalu namagciwane abuhlanganisayo egazini, manje elihlanzekile futhi elikwazi ukubuyiselwa esigulini.

U-Ingber nethimba lakhe bahlole idivayisi kumagundane angenwe yileli gciwane, futhi ngemva kokuthola ukuthi amagundane angenwe yileli gciwane ayesaphila ekupheleni kokwelashwa, wazibuza ukuthi ingabe idivayisi ingakwazi yini ukuphatha igazi lomuntu omdala ovamile (cishe amalitha amahlanu). Ngokudlulisela igazi lomuntu elinegciwane elifanayo kudivayisi ngo-89L/ihora, bathole idivayisi ikhiphe inqwaba yamagciwane phakathi kwamahora amahlanu.

Lapho inqwaba yamagciwane isusiwe egazini lesiguli, amasosha abo omzimba angakwazi ukuphatha izinsalela zawo ezibuthakathaka. U-Ingber unethemba lokuthi idivayisi izokwazi ukwelapha izifo ezinkulu, njenge-HIV ne-Ebola, lapho isihluthulelo sokusinda nokwelashwa okuphumelelayo siwukwehlisa izinga le-pathogenic egazini lesiguli ngaphambi kokuhlasela lesi sifo ngomuthi onamandla.