I-Cancer tumor genetics ivula indlela yenguquko yokwelashwa

Kuthiwani uma umzimba wakho ungalwa nomdlavuza njengoba wenza kumkhuhlane ojwayelekile? Ngokuqondile, kuthiwani uma amasosha akho omzimba engase aqede isimila? Ukuphumelela kwakamuva ocwaningweni lwezakhi zofuzo zesimila somdlavuza kuvulele iminyango immunotherapy, uhlobo olusha lokwelapha oluguqula amasosha akho omzimba abe umshini obulala umdlavuza. Ithimba lamazwe ngamazwe lososayensi, eliholwa ngu UCharles Swanton e-London, wathola ukuthi njengoba isimila siguquka, sithwala amaprotheni angaphezulu (ama-neoantigen) avamile kuwo wonke amaseli aso. Bathole uma amasosha omzimba egxile kulawo maprotheni, angabhubhisa wonke amangqamuzana omdlavuza emzimbeni. The Guardian iveza izindlela ezimbili kulokhu: 

1. Thatha i-biopsy kusuka eqhumeni, skena i-DNA yayo ukuze ubone ukuthi yimaphi amaprotheni akhona kuwo wonke amangqamuzana omdlavuza, futhi enze lokho kube okuhlosiwe. Amaseli amasosha omzimba avaleleke ngaphakathi kwesimila nawo ayakhishwa, aphindaphindeke futhi aphinde afakwe esigangeni Umjikelezo wesibili: 

2. Sebenzisa amaprotheni ukwenza umuthi wokugoma, ngaleyo ndlela amangqamuzana omzimba angawabona njengosongo futhi aqhubeke nokuwanciphisa. 

Zombili izindlela zokwelapha zisetshenziswa kanye “ne-checkpoint inhibitors,” okuyiyona evimba isimila ekubhubhiseni amaseli omzimba. Sekwenziwe lokho, amasosha omzimba okufanele akwenze ukufuna nokubhubhisa.  

Ubufakazi obuvela ocwaningweni, olushicilelwe ngo Isayensi, iphakamisa ukuthi ukwelapha okunjalo kusebenza kakhulu kumdlavuza onokuguquka okuningi, njengomdlavuza wamaphaphu kanye ne-melanoma. Kudingeka ucwaningo olwengeziwe ukuze kutholwe ukuthi lezi zindlela zokwelapha zingasebenza yini nomdlavuza oguqukile omncane, njengomdlavuza wesinye kanye nomdlavuza wendlala yesinye. Enye yezinto ezingezinhle ku-immunotherapy ukuthi iyabiza, ngakho akuwona wonke umuntu ongase akwazi ukuyifinyelela esikhathini esizayo.