Sabuwar inhala ta baka na iya maye gurbin allurar insulin ga masu ciwon sukari

Alfred E. Mann (shugaban kuma Shugaba na MannKind) da tawagarsa na masu haɓaka aikin likita suna yin ƙoƙari sosai don sauƙaƙe nauyin masu ciwon sukari. A farkon wannan shekarar, Mannkind ya fitar da wani inhaler na baki da sunan Afrezza. Za a iya amfani da ƙaramin mai busar baki mai girman aljihu azaman madadin allurar insulin a tsakanin masu ciwon sukari.

Hadarin ciwon sukari

Adadin Amurkawa miliyan 29.1 na fama da ciwon sukari, a cewar rahoton Rahoton Ciwon sukari na Kasa na 2014. Wannan yayi daidai da 9.3% na yawan jama'ar Amurka. Daga cikin miliyan 29 da ke fama da ciwon sukari a halin yanzu, miliyan 8.1 ba a gano su ba. Waɗannan lambobin sun fi firgita idan mutum ya fahimci cewa sama da kashi ɗaya cikin huɗu (27.8%) na mutanen da ke fama da ciwon sukari ba su san ciwon su ba.

Ciwon suga ya tabbatar da cewa cuta ce mai hatsarin gaske wacce ke matukar shafar rayuwar majinyatan da ke dauke da ita. Haɗarin mutuwa ga manya masu fama da ciwon sukari ya fi 50%, bisa ga rahoton Ciwon sukari na ƙasa. Kusan majiyyata 73,000 ne ake buqatar yanke wata kafa ta hannu saboda rashin lafiyarsu. Barazanar ciwon sukari na gaske ne, kuma samun ingantaccen magani mai amfani ga cutar ya zama dole. Ciwon sukari shi ne na bakwai da ya yi sanadiyar mutuwar mutane a Amurka a cikin 2010, wanda ya yi sanadiyar mutuwar mutane 69,071.

Nauyin ciwon sukari ba kawai zai shafi waɗanda aka gano suna da cutar ba. A cewar hukumar Cibiyar Kula da Cututtuka (CDC) miliyan 86, fiye da 1 cikin 3 Amurkawa a halin yanzu suna fama da pre-ciwon sukari. A halin yanzu kashi 9 cikin 10 na Amurkawa ba su san cewa suna da ciwon sukari ba, 15-30% na mutanen da ke da pre-ciwon sukari za su sami nau'in ciwon sukari na 2 a cikin shekaru biyar.

Haɗarin ciwon sukari tare da ƙididdiga masu ban tsoro da yake ɗauka sun sa ƙirar Mann, Afrezza, dacewa da jan hankali ga waɗanda ke fama da ciwon sukari na 1 ko 2. Ta hanyar daidaita matakan sukari na jini, wannan na iya taimakawa majiyyaci cikin rayuwar yau da kullun tare da ciwon sukari.

Mene ne amfanin?

Menene amfanin Afrezza? Menene ya bambanta da allurar insulin? Wadannan tambayoyi ne da aka amsa a lokacin jawabin da Mann, a Makarantar Magunguna ta John Hopkins.

Dangane da yadda iskar insulin foda ke aiki, Mann ya bayyana "Muna yin kwaikwayon abin da ainihin pancreas ke yi, muna yin insulin a cikin minti 12 zuwa 14 a cikin jini ... da gaske ya ɓace cikin sa'o'i uku". zuwa na yau da kullun na insulin. An bayyana a kan Lafiya.com, Ana ɗaukar insulin gajeriyar aiki tsakanin mintuna talatin zuwa awa ɗaya kafin cin abinci na majiyyaci, kuma yana ƙaruwa bayan sa'o'i biyu zuwa huɗu. 

Mann ya ci gaba da cewa, “Insulin ne ke ratayewa bayan an narkar da abinci wanda ke haifar da kusan dukkan matsalolin da ake samu ta hanyar maganin insulin. Yana haifar da hyperinsulinemia, hyperinsulinemia yana haifar da hypoglycemia, saboda hypoglycemia dole ne ku sami matakin glucose mai azumi. A halin yanzu kana cin kayan ciye-ciye duk rana, kuma hanta tana fitar da glucose don hana ka shiga suma, kuma shine abin da ke haifar da hauhawar ciwon sukari, yana farawa yana ci gaba har abada saboda ba ka da prandial. insulin."

Waɗannan ikirari na Mann game da Afrezza, ya zo daidai da sakamakon binciken kasa da kasa da aka gudanar a kan nau'in ciwon sukari na 2 daga Amurka, Brazil, Rasha da Ukraine. Masu bincike sun ƙare a cikin makafi biyu, binciken sarrafa placebo cewa marasa lafiya waɗanda aka sanya wa Afrezza, sun kasance ƙarƙashin ƙarancin kiba, kuma sun ga raguwa mai yawa a cikin matakan glucose na jini na postprandial.

Yada Afrezza

A kokarin wayar da kan marasa lafiya da ma’aikatan lafiya fa’idojin Afrezza, MannKind ya isar da fakitin samfurin 54,000 ga likitoci. Ta yin haka, MannKind yana fatan wannan zai haifar da 2016 mafi riba da fa'ida ga masu ciwon sukari, da kuma kamfanin. Ta hanyar isar da fakitin samfuri, yana haifar da kusanci mai ƙarfi tsakanin Afrezza da ƙwararrun likitocin, wanda kuma zai ba MannKind damar kafa jerin karawa juna sani na likitanci, tare da haɗa Afrezza cikin Kocin Sanofi - shirin kula da ciwon sukari kyauta ga marasa lafiya.

Makomar Afrezza da alama tana da haske sosai fiye da gajeriyar da ta gabata. Tun da aka ƙaddamar da Afrezza a ranar 5 ga Fabrairu, 2015, inhaler ɗin insulin ya kawo dala miliyan 1.1 kawai a cikin kudaden shiga. Wannan ya haifar da shakku a tsakanin waɗanda ke Wall Street waɗanda suka nemi cin nasara a kan wannan ƙirƙira na likitanci.

The slugging farkon kudi na Afrezza, kuma za a iya dangana ga tantance marasa lafiya dole ne kafin a iya rubuta su Afrezza. Dole ne marasa lafiya su yi gwajin aikin huhu (spirometry), don sanin ko waɗanda ke da yanayin huhu da suka rigaya za su iya amfani da maganin.

Bayanan sirri na Afrezza

An faɗi manyan abubuwa daga masu ciwon sukari waɗanda aka wajabta wa magani tare da Afrezza a matsayin tushen asalin insulin. Shafukan yanar gizo kamar Afrezzauser.com sun bayyana jin dadinsu da maganin. Dubban bidiyoyi na YouTube da shafukan Facebook sun taso a cikin 'yan watannin da suka gabata, suna bayyana ingantuwar lafiya ta hanyar iskar insulin.

Eric Finar, mai nau'in ciwon sukari na 1 na tsawon shekaru 22, ya fito fili yana goyon bayan Afrezza. Finar ya buga YouTube da yawa bidiyo game da amfanin lafiyar Afrezza, kuma ya yi iƙirarin HbA1c ɗin sa (ma'auni na matakan sukari na dogon lokaci a cikin jini), tun daga lokacin ya ragu daga 7.5% zuwa 6.3%, mafi ƙarancin HbA1c, tun lokacin amfani da Afrezza. Finar yana fatan kara rage HbA1c zuwa 5.0% ta ci gaba da amfani da Afrezza.

Ƙirƙirar madadin

Ta hanyar haifar da wayar da kan marasa lafiya da ƙwararrun likitoci, nan gaba da alama tana da haske ga Afrezza. Mutane da yawa masu fama da ciwon sukari na iya amfani da madadin shan insulin, yana taimakawa wajen inganta sakamakon lafiya. Wannan kuma zai tabbatar da zama ci gaban likita ga masu ciwon sukari waɗanda ke tsoron allura, ko kuma suke shakkar shan magani a bainar jama'a kafin a ci abinci.

A cewar wani Dokar FDA, “Kashi ɗaya bisa uku na duk ma’aikatan kiwon lafiya sun ba da rahoton cewa majinyata masu amfani da insulin sun damu da alluran da aka yi musu; irin wannan adadin mutane… suna ba da rahoton tsoratar da su. Rashin bin doka… matsala ce a cikin duka T1DM (nau'in ciwon sukari na 1) da marasa lafiya na T2DM, kamar yadda aka lura ta hanyar ƙuntatawa akai-akai ko watsi da allurar insulin.