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Wired
CRISPR proteins used with a process that amplifies RNA could be used to detect cancer cells
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The New England Journal of Medicine
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Futurism
Russian biologist Denis Rebrikov says he's found five couples who want him to use CRISPR to ensure their offspring do not inherit their deafness.
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MIT Technology Review
Can the powerful gene-editing tool CRISPR help cure diseases? Drug companies are racing to find out. A recently announced $300 million joint venture between Bayer AG and startup CRISPR Therapeutics—to develop new drugs for blood disorders, blindness, and congenital heart disease—is just the latest indication that the pharmaceutical industry is eager to find and develop…
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Cornell Chronicle
A Cornell researcher, who is a leader in developing a new type of gene editing CRISPR system, and colleagues have used the new method for the first time in human cells – a major advance in the field.
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Nature
Three studies showing large DNA deletions and reshuffling heighten safety concerns about heritable genome editing. Three studies showing large DNA deletions and reshuffling heighten safety concerns about heritable genome editing.
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Phys
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Wired
Tessera Therapeutics is developing a new class of gene editors capable of precisely plugging in long stretches of DNA—something that Crispr can’t do.
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New Scientist
Two people with beta thalassaemia and one with sickle cell disease no longer need blood transfusions after their blood stem cells were gene edited and put back in their bodies
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New Atlas
An incredible new breakthrough from scientists at ETH Zurich has, for the first time, demonstrated a new CRISPR method that can modify dozens of genes simultaneously, allowing for more large-scale cell reprogramming.
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Singularity Hub
China is seeing an explosion in CRISPR-based animal studies and embracing the gene-editing technology with unrivaled zeal.
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Nature
Parasitic genetic elements called transposons carry CRISPR machinery that is normally used against them by bacterial cells. This paradox has now been explained, with implications for gene-therapy research. RNA-guided transposition of DNA.
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Nature
Conventional CRISPR–Cas systems maintain genomic integrity by leveraging guide RNAs for the nuclease-dependent degradation of mobile genetic elements, including plasmids and viruses. Here we describe a notable inversion of this paradigm, in which bacterial Tn7-like transposons have co-opted nuclease-deficient CRISPR–Cas systems to catalyse RNA-guided integration of mobile genetic eleme
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Singularity Hub
The point isn’t to fuel public fear of the tool; rather, it’s to look far ahead at potential dangers and find preventive treatments or countermeasures.
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Nature
The gene-editing system could target a broad swathe of the genome with the help of versatile enzymes. The gene-editing system could target a broad swathe of the genome with the help of versatile enzymes.
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TechCrunch
CRISPR, the revolutionary ability to snip out and alter genes with scissor-like precision, has exploded in popularity over the last few years and is generally seen as the standalone wizard of modern gene-editing. However, it’s not a perfect system, sometimes cutting at the wrong place, not working as intended and leaving scientists scratching their heads. […]
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CNN
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a16z
News and trends covered this week -- all about the latest policy and in practice implication for CRISPR -- include:
* California law requiring labels for self-editing kits (that don't exist yet)
* Alliance (including 13 of the most active companies in gene editing for therapeutics) statement agains…
* California law requiring labels for self-editing kits (that don't exist yet)
* Alliance (including 13 of the most active companies in gene editing for therapeutics) statement agains…
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AAAS
New ability gives biologists tool to rework bacterial genomes in many ways
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Pub Med
The strategy described in this study could, in principle, be broadly adapted to CAR T-cells development to circumvent some of the possible hurdle of CAR T-cell manufacturing. This system essentially creates a CAR T-cell with an integrated functional rheostat.
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Wired
The overuse of antibiotics is brewing disaster for humanity.
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Nature
The selective regulation of bacteria in complex microbial populations is key to controlling pathogenic bacteria. CRISPR nucleases can be programmed to kill bacteria, but require an efficient and broad-host range delivery system to be effective. Here, using an Escherichia coli and Salmonella enterica co-culture system, we show that plasmids based on the IncP RK2 conjugative system can be used as de
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New Scientist
CRISPR gene editing can turn white fat cells into brown fat that burns energy, a technique that limited weight gain in mice and could potentially be used to treat obesity-related disorders
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Wired
Stanford scientists are exploring whether gene-editing technology can be used to fight pandemics. But so far, they have just one piece of a larger puzzle.
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Kurzgesagt – In a Nutshell
Designer babies, the end of diseases, genetically modified humans that never age. Outrageous things that used to be science fiction are suddenly becoming rea...
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Science Insider
Carl Zimmer, a science journalist, explains how the revolutionary new genome-editing tool CRISPR works.Zimmer is a columnist for The New York Times and the a...
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Two Minute Papers
❤️ Pick up cool perks on our Patreon page: https://www.patreon.com/TwoMinutePapers My talk and the full panel discussion at the NATO conference (I start at a...
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NPR
This could be a crucial year for the powerful gene-editing technique CRISPR as researchers start testing it in patients to treat diseases such as cancer, blindness and sickle cell disease.
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Technology Networks
Megatrends are overarching trends, ones that seed and embrace multiple market and technology developments. These trends already exist in our world today but are going to be even more important in the years to come. Here we highlight three technology megatrends that could be highly significant to our future.
