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The New Yorker
What if a drug could give you all the benefits of a workout?
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Eurekalert
A novel drug based on capsaicin, the compound that gives chili peppers their spicy burn, caused long term weight loss and improved metabolic health in mice eating a high fat diet, in new studies from the University of Wyoming School of Pharmacy. The drug, Metabocin, was designed to slowly release capsaicin throughout the day so it can exert its anti-obesity effect without producing inflammation or
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Business Insider
After 35 years of mediocre depression drugs, pharmaceutical companies are jazzed about several new drugs inspired by the club drug ketamine. Allergan, the multinational drugmaker known for Botox, recently dove into research on an injectable depression drug. Now they're going after an oral pill.
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The National Post
Although the eggs are in an immature state, the scientists are trying to discover how they were created, then work out a way to bring them to maturity
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CTV News
It's rare for researchers to discover a new class of drugs, but a University of Calgary microbiology professor recently did so -- by accident – and now hopes to revolutionize autoimmune disease treatment.
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Business Insider
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ABC
An Australian drug that melts away cancer in some stage four patients is given fast-track approval in the United States, but Australian patients cannot yet access it.
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BBC
An immunotherapy drug is described as a potential "game changer" in promising trial results on advanced cancers.
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The Conversation
Researchers use an algorithm designed to help robots move to figure out what's possible when designing new molecules in a promising class of pharmaceuticals.
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Endpoints
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Long Reads
New books about the opioid crisis — “Dopesick,” “Fight for Space” and “American Fix” — have different ideas about who’s to blame and what to do next. Our critic says regulating supply can have deadly consequences, and we need to address users' pain.
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CBC
Glybera is one of Canada's great scientific achievements that you have probably never heard about. UBC scientists spent decades developing the world’s first approved gene therapy. It is safe. It could save lives. But it's no longer available anywhere in the world — $1 million per dose was a problem.
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The National Post
The framework was announced by the Harper government in 2012, but sat on the back burner since then. Health Canada recently deleted all references from its…
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The Economist
Many generic drugs have too few manufacturers
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Peter Attia MD
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Medium
This is the first in a series of articles that aim to define the biopharmaceutical industry’s social contract with America, to examine practices that deviate from that contract, and to propose…
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University of Aberdeen
New drug has been shown to 'melt away' the fat inside arteries
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BBC
The drug combination has huge potential and would cost just "pennies a day", say the researchers.
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LA Times
Researchers have developed a new drug candidate that mimics the pain-killing effects of opioid analgesics with reduced adverse effects, at least in mice.
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MIT Technology Review
Scientists have designed a promising new painkiller that appears to separate the powerful pain dulling effects of synthetic opioids from side effects that include physical dependence, constipation, and potentially fatal respiratory depression. To find the new drug–named PZM21 and detailed in a paper published today in Nature–a research team at UCSF’s School of Pharmacy simulated…
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Pacific Standard Magazine
The answer involves both biology and economics, but the opioid crisis is forcing us to consider investing more in pain research.
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The Guardian
Key discovery around brains receptor proteins could help develop painkiller substitutes, raising hopes of an eventual end to global opioid addiction crisis
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Washington University in St. Louis
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Inverse
"This is a completely new chemical."
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Wired
Resiniferatoxin is 10,000 times hotter than the hottest pepper, and has features that make it promising as a painkiller of last resort.
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New Atlas
An incredible, first-of-its-kind trial testing the pain-killing properties of LSD microdoses has delivered the compelling suggestion that tiny, non-psychedelic doses of this infamous drug could serve as an effective analgesic.
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New York Times
The researchers and renegades bringing psychedelic drugs into the mental health mainstream.
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PsyPost
A commonly used anesthetic drug could help people with severe depression. Preliminary research published in the International Journal of ...
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Los Angeles Times
New research offers the prospect of limiting a stroke’s long-term damage with a drug that enhances the brain’s ability to rewire itself and promote recovery in the weeks and months after injury.
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Scitechdaily
McGill researchers' findings show that lithium may halt progression of Alzheimer's disease. There remains a controversy in scientific circles today regarding the value of lithium therapy in treating Alzheimer's disease. Much of this stems from the fact that because the information gathered to date
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The New York Times
A surprising drug has brought a kind of consciousness to patients once considered vegetative — and changed the debate over pulling the plug.
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Good News Network
The drugs metformin and bexarotene have been shown in trials to repair the myelin sheath in paitents with multiple sclerosis, or MS.
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UCSF
Using standard animal model of Down syndrome, scientists were able to correct the learning and memory deficits associated with the condition with drugs that target the body’s response to cellular stresses.
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New Atlas
We lose the ability to repair DNA damage as we age. But now a new study from MIT has found that reactivating a certain enzyme improves repair of DNA damage in neurons, which helps Alzheimer’s patients and others with cognitive decline.
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National Science Foundation
NSF's mission is to advance the progress of science, a mission accomplished by funding proposals for research and education made by scientists, engineers, and educators from across the country.
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BBC
It’s been dubbed “the end of modern medicine”. BBC Future asked experts to explain how we might avoid the worst effects of antibiotic resistance – a grand challenge of our age.
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Newsweek
Researchers used drug-resistant strains of bacteria collected from patients at the university's hospital for their experiments.
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BBC
Overuse of antibiotics has led them to becoming less and less effective to treat us when we’re sick – leaving scientists scrambling for a fix.
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BBC
Scientists warn this could lead to more outbreaks of disease and affect people who are already ill.
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Arstechnica
Long thought promising, viruses that target bacteria may be edging closer to use.
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UCLA
“We expect several of these combinations, or more, will work much better than existing antibiotics,” said Pamela Yeh, one of the study’s two senior authors and a UCLA assistant professor of ecology and evolutionary biology.
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MUCH
Canadian scientists identify new cellular target to weaken P. aeruginosa – a severe threat to patients with cystic fibrosis
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BBC
It uses a clever trick to sneak inside bacteria in order to kill the bugs.
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The Guardian
Warning comes as report shows 3 million common surgical procedures could be hazardous if infections become resistant to antibiotics
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KBR
Intron Biotechnology said it has signed a landmark deal for an investigational treatment for diseases caused by super bacteria.
The biotech firm announced on Tuesday that it clinched the licensing-out deal with Roivant Sciences for SAL200, a novel biologic to combat super bacteria.
The deal is worth $667.5 million (752.6 billion won), and Intron Bio is to separately receive running royaltie
The biotech firm announced on Tuesday that it clinched the licensing-out deal with Roivant Sciences for SAL200, a novel biologic to combat super bacteria.
The deal is worth $667.5 million (752.6 billion won), and Intron Bio is to separately receive running royaltie
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New York Times
The rise of Candida auris embodies a serious and growing public health threat: drug-resistant germs.
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WHO
UN, international agencies and experts today released a groundbreaking report demanding immediate, coordinated and ambitious action to avert a potentially disastrous drug-resistance crisis. If no action is taken - warns the UN Ad hoc Interagency Coordinating Group on Antimicrobial Resistance who released the report – drug-resistant diseases could cause 10 million deaths each year by 2050 and da
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Nature
The selective regulation of bacteria in complex microbial populations is key to controlling pathogenic bacteria. CRISPR nucleases can be programmed to kill bacteria, but require an efficient and broad-host range delivery system to be effective. Here, using an Escherichia coli and Salmonella enterica co-culture system, we show that plasmids based on the IncP RK2 conjugative system can be used as de
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KU Leuven
Bioscience engineers from KU Leuven in Belgium have developed a new antibacterial strategy that weakens bacteria by preventing them from cooperating. Unlike with antibiotics, there is no resistance to this strategy.
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MIT Technology Review
Using a new machine-learning algorithm, MIT researchers have identified a powerful antibiotic that can kill a wide range of species of pathogenic bacteria, including some that are resistant to all known antibiotics.
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Phys
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AAAS
Much of the controversy surrounding the gene-editing technology called CRISPR/Cas9 centers on the ethics of germline editing of human embryos to correct disease-causing mutations. For certain disorders such as muscular dystrophy, it may be possible to achieve therapeutic benefit by editing the faulty gene in somatic cells. In proof-of-concept studies, Long et al. , Nelson et al. , and Tabebordbar
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3Ders
3D printing technology enables doctors and pharmaceutical companies to manufacture drugs tailored to the specific needs of individual patients--taking into account their age, weight, race, and kidney and liver functions to increase the effectiveness while reducing side-effects. Yet what are the potential effects of 3D printed drugs on the medical industry?
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Nature
A non-profit organization is proving that new drugs don't have to cost a fortune. Can its model work more broadly?
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Phys
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Medical News Today
A new vaccine combination has proven successful in mouse models of Alzheimer's, new study reveals, and it could be tested in humans within 3-5 years.
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SingularityHub
Exploring every chemically possible drug is humanly impossible, which is why companies are developing drug discovery AI to do the much of the work for us.
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VICE
The door is open for making drugs on-site in doctors' offices, or even in space.
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AAAS
Behold the rise of the machines. It's been going on for a while, but there are landmarks along the way, and we may have just passed another one with the
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Futurity
A new method for "fishing" in large collections of DNA-encoded chemical libraries could make finding new drugs a lot quicker.
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Kurzweil AI
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Futurity
When reserchers used their new method on epilepsy, they found a new drug target. The approach could cut the time it takes to find other drugs, too.
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Science News
A new AI that judges whether drugs will interact with certain proteins can train on data from multiple sources while keeping that info secret.
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Techxplore
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Digital trends
Drug companies spend billions developing and protecting their trademark pharmaceuticals. In a breakthrough, researchers have demonstrated an A.I. which can find new methods for producing existing drugs in a way that doesn’t infringe on existing patents. Here's how it works.
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AAAS
STAT is reporting that IBM has stopped trying to sell their "Watson for Drug Discovery" machine learning/AI tool, according to sources within the company. I
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Harvard Business Review
It will help patients and bring new treatments to market faster.
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Medium
Unveiling the first fully automated, robotic factory that is able to mass-personalize pharmaceutical products.
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South China Morning Post
Artificial intelligence took three weeks to identify six substances that block an enzyme responsible for fibrosis and other illnesses, according to paper.
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Deloitte
Drug discovery is long, expensive and often unsuccessful. AI-enabled solutions are transforming the process and shifting health care towards a future where medicine is personalised, predictive, preventative and precise.
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C&EN
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a16z
One of the defining characteristics in an industrial revolution is the fundamental shift from a bespoke, artisan process to an industrialized, engineerable, repeatable one. In this video, General Partner on the Bio Fund Vijay Pande describes how we are in the middle of a revolution driven by AI and machine learning that is industrializing discovery itself.
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Royal Society of Chemistry
Ion mobility spectrometry is transforming the field of biomolecule research, with Waters technology at the forefront of this vital analytical innovation
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Linkedin
From diagnosis and surveillance to psychology and genetics, crowdsourcing has had a growing impact on how health-related questions get addressed. And not only has it accelerated this process, but crucially it has also widened accessibility to healthcare.
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The Guardian
Firm is recruiting artificial intelligence specialists and developing new genomics lab
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Contract Pharma
Insights on the major changes shaping the clinical landscape
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Deloitte
Learn how artificial intelligence (AI) in clinical trials can improve clinical cycle times while reducing the cost and burden of clinical development.
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Vox
Antibiotic resistance has put us at risk of superbugs. AI can help.
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MIT Technology Review
The news: IBM has built a new chemistry lab called RoboRXN in the cloud. It combines AI models, a cloud computing platform, and robots to help scientists design and synthesize new molecules while working from home. How it works: The online lab platform allows scientists to log on through a web browser. On a blank…
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Uncubed
Startups like Capsule, Round Health, and Nurx are upgrading the drugstore experience with vitamin and prescription drug delivery
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Referral MD
The healthcare industy is evolving. Check out the healthcare technology trends that well be opportunties in for the healthcare industry in 2019.
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Pharmaceutical Journal
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Pharmaceutical Journal
The Pharmaceutical Journal from the Royal Pharmaceutical Society
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The Local
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MobiHealthNews
Whether by managing payments, connecting consumers to reimbursement options or just manufacturing cheap drugs themselves, these companies are taking aim at a problem that's building to a crisis.
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Pharmaceutical Processing World
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Business Insider
Walmart's vet clinics will provide services such as exams and vaccinations at discounts of up to 60% off.
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Analytics India Magazine
"Previously, it used to take a year to 18 months to get a product approved but now it happens in less than six months."
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Hit Infrastructure
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Open PR
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Quartz
Africa alone accounts for 42% of globally detected cases of substandard and fake medical products, says WHO
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The Atlantic
Machine learning could train software to spot verbal tics associated with schizophrenia, depression, and bipolar disorder.
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Forbes
The pharmaceutical industry is changing. Here's what the research says about the role biotech will play in its evolution.
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National Geographic
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Vox
Some of the consequences of thawed permafrost seem almost apocalyptic.
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Technology Review
Women directly buying their birth control online are getting a glimpse of what the future of medicine could be. And according to a study in the New England Journal of Medicine published today, it’s—drum roll—pretty darn safe. The study—titled “A Study of Telecontraception”—recruited seven “secret shoppers” in California who purchased birth control from nine vendors…
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Deloitte
The pace and scale of medical and scientific innovation is transforming the biopharma industry. The need for better patient engagement and experience is spurring new business models. AI is rising across biopharma.
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Vox
Because of antibiotic resistance, 1 person in the US dies every 15 minutes.
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Euronews
Web Summit 2019: AI and drug development mark new era for pharma
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Pharmaceutical Journal
Access to data will transform the NHS — it’s time pharmacists got to grips with clinical informatics, says Andrew Davies.
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Spend Matters
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Business Insider
Industry experts predict that pharma companies will become more active acquirers of direct-to-consumer drug delivery upstarts in 2020.
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Nurse
The pressures on new graduate nurses to transition from education to practice are often too much to take, causing RNs meant to fuel nursing’s workforce pipeline in the coming decades to question their career choice. One thing that can ease the transition and help retain new nurses is nurse precepting.
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Pharmaceutical Journal
The Pharmaceutical Journal from the Royal Pharmaceutical Society
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The Independent
Employers will offer substances which enhance cognitive abilities, while the have-nots will be left open to more health risks than ever
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Australian Journal of Pharmacy
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Pharmaceutical Journal
The Pharmaceutical Journal from the Royal Pharmaceutical Society
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Australian Journal of Pharmacy
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Malay Mail
KUALA LUMPUR, March 29 — The Malaysian Pharmaceutical Society (MPS) is asking Putrajaya to extend to its members the RM600 monthly allowance for frontline medical workers announced in the Covid-19 stimulus package. In a statement today, MPS president Amrahi Buang said pharmacists were also...
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Deloitte
Explore what the future of the pharmaceutical industry holds and how health interventions may impact business models in life sciences.
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India Today
The lockdown and curfew in many states has broken the medicine supply chain. The pharma unit owners say they were compelled to stop manufacturing activity as some ancillary units that make foil, packaging material and printers have shut down.
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The Economist
Companies could switch from primarily making generics to producing higher-margin licensed drugs
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STAT Trade Times
Worldwide Flight Services’ (WFS’) investment in 12 dedicated pharma facilities at airports in Europe, the United States and Africa generated significant increases in time- and temperature-sensitive volumes in the first five months of 2020
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Chemistry World
Drug trials have become a casualty of Covid-19, but the pandemic is also prompting change
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Business Standard
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Pharmaphorum
Digital in itself is no longer a way for the industry to show its innovativeness and gain a competitive advantage – it should be considered as a pre-condition for staying relevant on a transformed market
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Life Science Leader
For regenerative medicine as a field to truly advance, it would require an intricate interplay between manufacturers, hospital systems, physicians,...
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BBC
The internet retail giant's move comes as US tech firms are investing billions of dollars in India.
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BioPharma Dive
BioPharma
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Deloitte
This report explores the potential for AI technologies to improve the safety, productivity and costs of the biopharma supply chain and manufacturing processes.
