Nano-daawo ayaa la filayaa inay daweyso jirrooyinka daba-dheeraada

Haddi ay tahay timaha daataan, lallabo, ama kaniiniga aan dhamaadka lahayn, qof kasta oo waligiis la kulmay kansar wuu ogyahay in daawaynta ay noqon karto mid murugo leh. Kiimoterabiga dhaqameedku wuxuu awood u leeyahay inuu weeraro unugyada caafimaadka qaba marka lagu daro kuwa dhibka leh ee xun, taasoo keentay dhibaatooyinka aan soo sheegnay. Laakiin ka waran haddii aan daweyn karno kansarka iyada oo aan lahayn waxyeellooyin daciif ah? Maxaa dhacaya haddii aan ku beegsan karno daroogooyinka unugyada dembiilayaasha oo keliya oo aan u sii deyn karno si sax ah marka aan u baahanahay?

Adah Almutairi, oo ah maamulaha Xarunta Sare ee Nanomedicine iyo Injineerinka ee Jaamacadda California, San Diego (UCSD), ayaa soo saartay tignoolajiyad ku lug leh nanoparticles-ka-shaqeeya iftiinka oo awood u leh inay sidaas sameeyaan. Isticmaalka walxaha miisaanka 100nm, Almutairi iyo kooxdeeda cilmi-baarista waxay dhigteen molecules daroogada kubbado yaryar oo yaryar oo ay ugu yeerto nanospheres. Marka daawaynta loo maamulo, daawadu waxay ku xidhnaan doontaa kubbadaha, ma awoodaan inay burburiyaan unugyo aan waxba galabsan, oo aan laga shakin. Si kastaba ha ahaatee, marka ay soo gaadho iftiinka infrared-ku dhow, nanospheres-yadu way kala baxaan, iyaga oo sii daaya waxa ku jira. Saameyntu waa caddahay: haddii aan awood u yeelan karno xakameynta saxda ah goorta iyo meesha daawooyinka loo baahan yahay, kaliya ma kordhin karto qaadashada daroogada, saameynaha soo raaca ayaa si weyn hoos loogu dhigi karaa.

"Waxaan rabnaa in hababkan ay si sax ah u shaqeeyaan, si loo yareeyo saameynta daroogada ee aan la beegsanayn," Almutairi ayaa yidhi.

Laakin ikhtiraacida Almutairi ma aha mid gaar u ah mabda'a. Dhab ahaantii, gaarsiinta daroogooyinka la beegsaday ayaa safka hore kaga jirtay cilmi baarista qaybta soo koraysa ee nanomedicine in muddo ah. Saynis yahanadu waxay markii hore isku dayeen in ay dawooyinka ku geeyaan liposomes, vesicles spherical kuwaas oo si dabiici ah isu urursada sababo la xidhiidha sifooyinka fosfolipids ka kooban yahay.

"Dhibaatada liposomes-ku waa sababta oo ah aad bay u nool yihiin, ma ahan kuwo deggan," ayuu yiri Xiaosong Wang, oo ah borofisar ku takhasusay nanotechnology ee Jaamacadda Waterloo. "Si sahal ah ayay u kala tagayaan, sidaa darteed aad uguma tayo badna gudbinta daroogada."

Shaybaarka Wang, oo ku yaal Machadka Waterloo ee Nanotechnology, wuxuu sameeyaa cilmi-baaris ku saabsan isku-ururinta birta-ku-jirta ee copolymers block - oo la mid ah nuxurka liposomes, laakiin aad u xasilloon oo aad u kala duwan. Magnetism, redox, iyo fluorescence waa qaar ka mid ah sifooyinka soo jiidashada leh ee ku jira biraha kuwaas oo leh codsiyada xiisaha leh ee daawada iyo wixii ka baxsan.

"Waxaa jira waxyaabo badan oo ay tahay inaad tixgeliso markaad codsanayso polymers-ka kooban ee biraha ku jira gaarsiinta daroogada. Arrinta ugu weyni waa sunta [ama sida ay suurtogal u tahay inay wax u dhinto jirkeena]. Markaa waxaa jira biodegradability, ”ayuu yidhi Wang.

Taasi waa meesha qaabka Almutairi laga yaabo inuu dahab ku dhuftay. Ma aha oo kaliya nanospheres-keeda "waxay u deggan yihiin sida dhagax weyn", laakiin sidoo kale waa ammaan buuxa. Sida laga soo xigtay iyada, nanospheres-ku waxay "joogi karaan ilaa hal sano ka hor inta aan si ammaan ah loo dumin," sida lagu caddeeyey tijaabooyinka xayawaanka ee jiirarka. Muhiimada ay leedahay taasi waa mid aad u qiimo badan, muujinta sun la'aanta ayaa laga yaabaa inay noqoto tillaabadii ugu horeysay ee ay ku hesho hal-abuurkeeda suuqa.