Ukubaluleka kwendawo (i-T-cell receptor) yendawo engokoqobo

Ama-T-cell sekuyisikhathi eside aqashelwa njenge-linchpin yamasosha omzimba. Ukuhlonzwa kwezinto ezingase zibe yingozi (njengezinto ezithathelwanayo noma amaseli omdlavuza) kuncike ekusebenziseni ama-receptors ahlakazeke endaweni ye-T-cell. Ngamanye amazwi: "Uphawu oluphawulekayo lwamasosha omzimba aguquguqukayo yikhono lama-T-cell okubona ama-antigen. "

Lapho izingozi sezitholakele, kuthunyelwa izimpawu zamakhemikhali ezinto eziphilayo ukuze zihlasele abahlaseli. Ukuba nama-T-cell anama-receptors asebenzayo ngokuvamile kucatshangwa ukuthi kuyisimo esifanele sokuphendula okuqinile kwamasosha omzimba. 

Ucwaningo lwamanje kubuchwepheshe be-imaging be-molecular lubekela inselele lokhu kucatshangwa mayelana ne-T-cell nokusebenza kwayo. Ngokwalolu cwaningo, ukuba nama-T-cell anama-receptors acushiwe kungase kungabalulekile kangako Kanjani futhi lapho ama-receptors afakwa. 

Abacwaningi eNyuvesi yaseNingizimu Wales babonise ukuthi ukwenziwa kusebenze kwama-T-cells' surface receptors kungase kuhlobane nokusabalalisa kwawo. Okungukuthi: lapho ama-receptors ehlangene kakhulu, amathuba angcono iseli onalo okubona i-antigen kanye nokufaka isivikelo. 

Ucwaningo luphakamisa ukuthi uma ama-receptor angaphezulu engekho kuphethini efanelekile yokukhiywa ku-antigen, inani lama-T-cell akhona lingase lingenzi mehluko wangempela. Ngokuphambene, inqobo nje uma ama-receptors esezindaweni eziyinhloko, angasebenza kahle kakhulu emisebenzini yawo ebophayo.

Ukubekwa kwe-T-cell njengokuthuthukiswa kwezokwelapha

Lolu lwazi lungasiza ekuthuthukisweni kwezokwelapha esikhathini esizayo. Ososayensi balindele ukusebenzisa i-nanotechnology ukuze baphinde bahlele ama-receptors eduze nendawo yama-T-cells abe amaqoqo asebenza kangcono. Akukhona nje kuphela ukuthi ukusebenza kwama-receptors kungathuthukiswa ngale ndlela, kunethuba lokuqasha ama-T-cell amaningi endaweni yokuzivikela. Lokhu kungenziwa ngokuvula kabusha ama-receptors kumaseli "aphelile". 

Ukufuna izindlela ezintsha zokwandisa izivikeli zomzimba womuntu kungaholela ekwelashweni okuqondiswe kakhudlwana, okunamandla okuntula imiphumela engemihle ngezinye izikhathi ezilethwa ama-antibiotics noma imishanguzo elwa nomdlavuza. Ukushintsha indawo yama-T-cell receptors kungase kube isinyathelo sokuqala sokukhulisa lezi zivikelo zemvelo.