Shin sabon ci gaba a cikin maganin antibody zai iya canza yadda muke bi da HIV?

A cewar WHO, akwai kimanin mutane miliyan 36.7 da ke dauke da kwayar cutar HIV a fadin duniya. Wannan kwayar cutar tana haifar da mutuwar mutane miliyan 1.1 a kowace shekara, amma duk da biliyoyin daloli da shekaru da yawa na bincike, har yanzu babu magani ko rigakafin.

Kwanan nan, masu bincike a Jami'ar Rockefeller da Cibiyar Kiwon Lafiya ta Kasa sun gudanar da wani bincike game da irin wannan kwayar cuta, SHIV (Simian-Human Immunodeficiency Virus), da aka samu a cikin birai, kuma sun tabbatar da cewa haɗuwa da ƙwayoyin rigakafi da aka ba su da wuri bayan kamuwa da cuta zai iya taimakawa mai gida wajen sarrafa kwayoyin cutar. ƙwayar cuta. Koyaya, don fahimtar abin da wannan ci gaban ke nufi ga makomar HIV a cikin mutane dole ne mu kalli yadda kwayar cutar ke aiki.   

Wayar cutar    

HIV cuta ce mai ban tsoro. Yana tafiya bayan sel a cikin tsarin garkuwar jikin ku - macrophages, sel dendritic, da ƙwayoyin T- kuma suna kaiwa ga furotin da ake kira CD4. Wannan yana ba HIV damar da gaske “hack” kariyar garkuwar jikin ku da sarrafa martaninta yayin kamuwa da cuta. Wannan tsari yana haifar da ƙwayoyin rigakafi su mutu. Kwayar cutar kuma na iya kashe ƙwayoyin da ba su da tasiri a cikin tsarin rigakafi. Don yin muni, a cewar CID, HIV na iya canzawa sau da yawa a cikin kwanaki goma na farkon kamuwa da cuta fiye da duk sanannun nau'in mura a tare.   

A halin yanzu, hanyar da muke bi da HIV a cikin mutane ta hanyar ART ko maganin rigakafi. Wannan maganin yana aiki ne ta hanyar hana kwayar cutar HIV sake maimaitawa, wanda baya ga kiyaye ƙarin ƙwayoyin rigakafi a raye kuma yana taimakawa hana yaduwar cutar. Duk da haka, wannan nau'i na magani zai iya barin kwayar cutar HIV a cikin jiki, kuma yana shirye ya yi tsalle da zarar magani ya rushe.  

Bincike da Bincike   

Masu bincike sun dauki birai goma sha uku suka yi musu allurar SHIV; Bayan kwana uku an basu maganin rigakafi guda biyu na cikin jini. Jiyya na farko ya kasance mai ban sha'awa, kuma nauyin kwayar cutar ya ragu zuwa kusan matakan da ba a iya ganowa ba kuma ya zauna a wannan lokacin har tsawon kwanaki 56-177. Babban jigon gwajin shi ne abin da aka gani da zarar an daina jinyar kuma birai ba sa ɗauke da ƙwayoyin rigakafi. Da farko dai kwayar cutar ta sake bulla a cikin goma sha biyu daga cikin dabbobin, amma bayan watanni 5-22 shida daga cikin birai sun sake samun iko da kwayar cutar, matakinsu ya koma kasa zuwa adadin da ba a iya ganowa ba, kuma suka zauna a can na karin watanni 5-13. Wasu birai guda hudu ba su sami cikakken iko ba amma sun nuna ƙananan matakan ƙwayoyin cuta da matakan lafiya na ƙwayoyin garkuwar jiki. Gabaɗaya, 10 daga cikin 13 da aka gwada gwajin sun amfana da maganin.