Hiki paha i kahi hoʻomohala hou i ka antibody therapy ke hoʻololi i ke ʻano o kā mākou mālama ʻana i ka maʻi HIV?

Wahi a WHO, aia ma kahi o 36.7 miliona mau kānaka e noho ana me ka maʻi HIV a puni ka honua. ʻO kēia maʻi maʻi he 1.1 miliona mau make i kēlā me kēia makahiki, akā ʻoiai he mau piliona kālā a me nā makahiki o ka noiʻi ʻana, ʻaʻohe lāʻau lapaʻau a i ʻole kano.

I kēia mau lā, ua hana nā mea noiʻi ma ke Kulanui ʻo Rockefeller a me ka National Institute of Health i kahi noiʻi e pili ana i kahi maʻi like, SHIV (Simian-Human Immunodeficiency Virus), i loaʻa i loko o nā monkey, a ua hōʻoia i ka hui pū ʻana o nā antibodies i hāʻawi ʻia ma hope koke o ka maʻi hiki ke kōkua i ka mea hoʻokipa e hoʻomalu i ka maʻi. virus. Eia nō naʻe, no ka hoʻomaopopo ʻana i ke ʻano o kēia holomua no ka wā e hiki mai ana o ka maʻi HIV i ka poʻe pono mākou e nānā i ke ʻano o ka hana ʻana o ka maʻi.   

ʻO ka Virus    

He maʻi paʻakikī ka maʻi HIV. Hele ʻo ia ma hope o nā cell i loko o kāu ʻōnaehana immune-macrophages, dendritic cell, a me T cell- a hitchhikes i kahi protein i kapa ʻia CD4. ʻAe kēia i ka HIV e "hack" i nā pale kūlohelohe kūlohelohe o kou kino a hoʻoponopono i kāna pane i ka wā o kahi maʻi. ʻO kēia kaʻina hana e make ai nā cell immune. Hiki nō hoʻi i ka maʻi ke pepehi i nā pūnaewele pili ʻole i loko o ka ʻōnaehana pale. E ʻoi aku ka hewa, e like me ka CID, hiki i ka maʻi HIV ke hoʻololi i nā manawa he nui i nā lā he ʻumi mua o ka maʻi ma mua o nā maʻi maʻi i ʻike ʻia.   

I kēia manawa, ʻo ke ʻano o kā mākou mālama ʻana i ka maʻi HIV i ke kanaka ma o ART a i ʻole antiretroviral therapy. Hoʻohana ʻia kēia lāʻau lapaʻau ma ke kāpae ʻana i ka maʻi HIV mai ka hana hou ʻana, ʻo ia hoʻi ka mālama ʻana i nā cell immune hou aku e kōkua i ka pale ʻana i ka laha ʻana o ka maʻi. Eia nō naʻe, hiki i kēia ʻano lapaʻau ke waiho i ka maʻi HIV e hūnā i loko o ke kino, a ua mākaukau ʻo ia e lele i ka wā e hoʻopau ʻia ai ka lāʻau.  

Haʻawina noiʻi a me nā ʻike   

Ua lawe nā kānaka noiʻi i ʻumikumamākolu mau monkey a hoʻoinu iā lākou me ka SHIV; ʻekolu mau lā ma hope mai ua hāʻawi ʻia lākou i nā hoʻonā intravenous o ʻelua mau antibodies ākea ākea. Ua hoʻohiki ka hoʻomaʻamaʻa mua ʻana, a ua hoʻohaʻahaʻa ka viral load i nā pae i ʻike ʻole ʻia a noho i kēlā manawa no 56-177 mau lā. ʻO ke kumu o ka hoʻokolohua ʻo ia ka mea i ʻike ʻia i ka wā i pau ai ka mālama ʻana a ʻaʻole lawe hou nā monkey i nā antibodies. Initially, ka maʻi maʻi rebounded i ka umikumamalua o na holoholona, ​​aka, 5-22 mahina ma hope eono o na monkeys spontaneously loaa hou ka mana o ka maʻi, ko lakou pae i hāʻule hoʻi i lalo i ka undetectable helu, a noho ma laila no ka hou 5-13 mahina. ʻEhā mau monkey ʻē aʻe ʻaʻole i loaʻa hou ka mana piha akā ua hōʻike i nā pae pāpaʻu o ka maʻi a me nā pae olakino o nā pūnaewele ʻōnaehana pale. ʻO ka holoʻokoʻa, 10 o nā kumuhana hoʻāʻo 13 i pōmaikaʻi mai ka mālama ʻana.