Thandizo laposachedwa la matenda a Parkinson lidzatikhudza tonse
Thandizo laposachedwa la matenda a Parkinson lidzatikhudza tonse
Ndine waku Canada wazaka 32 yemwe adapezeka ndi matenda a Parkinson zaka zitatu zapitazo. Mwezi wa July wapitawu ndinasiya ntchito ndipo ndinabwerera kunyumba kuti ndikafufuze kaye za matendawa ndikuphunzira zonse zomwe ndingathe ponena za matendawa ndi njira zothandizira zomwe ndingapeze. Matendawa andithandiza kuti ndilowetse phazi langa m'malo omwe sindikanapitako ndipo andidziwitsa anthu ena odabwitsa omwe ntchito yawo idzasintha dziko lapansi. Zandipatsanso mwayi wowonera sayansi ikugwira ntchito pomwe ikukankhira m'mbuyo malire a chidziwitso chathu. Ndazindikira kuti mankhwala omwe akupangidwira PD sikuti amakhala ndi mwayi weniweni wa tsiku limodzi kupanga matendawa kukhala akale kwa ine ndi ena omwe adakanthidwa nawo, koma ali ndi ntchito zotalikirapo zomwe zidzafalikira kwa aliyense komanso kusintha kwenikweni zochitika za munthu.
Zomwe zachitika posachedwa zathandiza asayansi kumvetsetsa bwino za matendawa zomwe zawonetsanso momwe ubongo wathu umagwirira ntchito. Zatsogoleranso kumankhwala atsopano omwe ofufuza ambiri amakhulupirira kuti apezeka kwa anthu omwe ali ndi Parkinson mkati mwa zaka 5 mpaka 10 zikubwerazi. Koma izi zidzangokhala mtundu 1.0 wamankhwala awa, tikamakwaniritsa njira izi zidzagwiritsidwa ntchito ku matenda ena mu mtundu 2.0 (zaka 10 mpaka 20) komanso kwa anthu omwe akuwoneka kuti ali ndi thanzi labwino mu mtundu 3.0(20 mpaka zaka 30).
Ubongo wathu ndi wosokonekera wa ma neuron omwe amapanga ma neurotransmitters omwe amayambitsa mphamvu zamagetsi zomwe zimadutsa muubongo ndikutsika mumtsempha wathu wapakati kuti auze mbali zosiyanasiyana za matupi athu zoyenera kuchita. Njira zama neural izi zimagwiridwa pamodzi ndikuthandizidwa ndi maukonde ambiri a maselo osiyanasiyana, iliyonse ili ndi ntchito yakeyake koma zonse zimalunjika kukukhalabe ndi moyo ndikugwira ntchito moyenera. Zambiri zomwe zimachitika m'matupi athu zimamveka bwino masiku ano, kupatula ubongo. Pali ma neuroni 100 biliyoni muubongo amitundu yosiyanasiyana komanso kulumikizana kopitilira 100 thililiyoni pakati pa ma neuron amenewo. Iwo ali ndi udindo pa chilichonse chimene mukuchita ndi chimene muli. Mpaka posachedwapa sitinamvetsetse bwino momwe zidutswa zonsezo zimagwirizanirana, koma zikomo kwambiri pakufufuza mwatsatanetsatane za matenda a ubongo tsopano tikuyamba kumvetsetsa momwe zonsezi zimagwirira ntchito. M'zaka zikubwerazi zida ndi njira zatsopano, pamodzi ndi kugwiritsa ntchito makina ophunzirira, zidzalola ochita kafukufuku kufufuza mozama ndi ambiri akukhulupirira kuti kwangotsala nthawi kuti tipeze chithunzi chonse.
Zomwe tikudziwa, kupyolera mu phunziro ndi kuchiza matenda a neurodegenerative monga Parkinson's, Alzheimer's, ALS, ect., Ndikuti pamene ma neuron afa kapena zizindikiro za mankhwala sizimapangidwanso kupyola malire ena, mavuto amayamba. Mwachitsanzo, mu Matenda a Parkinson, zizindikiro sizimatuluka mpaka pafupifupi 50-80% ya ma neuron omwe amapanga dopamine m'madera ena a ubongo atamwalira. Komabe ubongo wa aliyense umasokonekera pakapita nthawi, kufalikira kwa ma free radicals ndi kudzikundikira kwa mapuloteni olakwika omwe amapezeka kuchokera ku chakudya chosavuta komanso kupuma kumabweretsa kufa kwa cell. Aliyense wa ife ali ndi kuchuluka kosiyanasiyana kwa ma neuron athanzi m'makonzedwe osiyanasiyana ndipo ichi ndichifukwa chake pali kusiyanasiyana kwa luntha la kuzindikira kwa anthu. Kugwiritsa ntchito mankhwala omwe akupangidwa lero kuti akonze zofooka mwa anthu omwe ali ndi matenda osiyanasiyana tsiku lina adzagwiritsidwa ntchito mwa anthu omwe ali ndi milingo yocheperako ya neuron inayake mu gawo linalake la ubongo.
Kuwonongeka kwa minyewa komwe kumabweretsa matenda a minyewa ndi chifukwa cha kukalamba kwachilengedwe. Kuzindikira komanso kumvetsetsa zinthu zomwe zimapangitsa kuti anthu azikalamba kwachititsa kuti anthu ambiri azachipatala akhulupirire kuti tikhoza kulowererapo ndikuyimitsa kapena ngakhale. sinthani ukalamba palimodzi. Njira zochiritsira zatsopano zikugwiritsidwa ntchito kuti athetse mavutowa. Zina mwazosangalatsa kwambiri ndi…
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Njira zonsezi zili pachimake ndipo ziwona kusintha kosalekeza m'zaka zikubwerazi. Ndizotheka kuti anthu omwe akuwoneka kuti ali athanzi akadzakhala angwiro azitha kupita ku chipatala, kukayezetsa ubongo wawo, kuwerengera ndendende zomwe mbali zaubongo wawo zili ndi milingo yabwino kwambiri ndikusankha kuwonjezera magawowo kudzera m'modzi kapena zingapo mwazosiyanasiyana. njira zomwe tazitchula pamwambapa.
Mpaka pano zida zomwe zilipo zomvetsetsa ndikuzindikira matenda ambiri zakhala zosakwanira ndipo ndalama zopangira kafukufuku wofuna zakhala zikusowa. Komabe pali masiku ano ndalama zambiri zikutsanuliridwa pakufufuza koteroko ndipo anthu ambiri akuyesetsa kuthana nawo kuposa kale. M'zaka khumi zikubwerazi tidzapeza zida zatsopano zodabwitsa zothandizira kumvetsetsa kwathu. Ntchito zoyembekezeka kwambiri zimachokera ku Ntchito ya ubongo waumunthu ku Europe ndi Ntchito yaubongo ya U.S omwe akuyesera kuchitira ubongo zomwe polojekiti yamtundu wa munthu idachita kuti timvetsetse za genome. Ngati zipambana zidzapatsa ofufuza chidziwitso chomwe sichinachitikepo m'mene malingaliro amapangidwira pamodzi. Kuphatikiza apo, pakhala pali ndalama zochulukirapo zamapulojekiti ochokera kumabungwe abizinesi monga momwe Google idapangidwira Ma laboratories a Calico, ndi Paul Allen Institute for Brain Science, Chan Zuckerberg Initiative, ndi Zuckermen mind, brain and behaviour Institute, Gladstone Institute, ndi American Federation for Aging Research, Buck Institute, Zolemba ndi Yambani, kungotchulapo zochepa chabe, osatchulanso ntchito zonse zatsopano zimene zikuchitika m’mayunivesite ndi m’makampani opanga phindu padziko lonse lapansi.
