Izindlela zokwelapha zakamuva zesifo sikaParkinson zizosithinta sonke

NgingowaseCanada oneminyaka engu-32 ubudala kwatholakala ukuthi nginesifo sikaParkinson eminyakeni emithathu edlule. Kulo Julayi odlule ngiyekile umsebenzi futhi ngabuyela ekhaya ukuze ngihlole lesi sifo kuqala futhi ngafunda konke engingakwazi ngaso kanye nezindlela zokwelapha engingazithola. Lesi sifo singenze ngakwazi ukufaka unyawo lwami emnyango ezindaweni ebengingeke ngiye kuzo futhi singethule kubantu abaphawulekayo umsebenzi wabo ozoshintsha umhlaba. Kunginikeze nethuba lokubona isayensi isebenza njengoba ihlehlisa umngcele wolwazi lwethu. Ngiye ngabona ukuthi izindlela zokwelapha ezenzelwe i-PD azigcini nje ngokuba nethuba langempela lokuthi ngelinye ilanga ngenze lesi sifo sibe yinto yesikhathi esidlule kimi nakwabanye abahlaselwe yiso, kodwa sinezicelo ezifinyelela kude ezizodlulela kuwo wonke umuntu futhi. shintsha ngokuyisisekelo okuhlangenwe nakho komuntu.

Intuthuko yakamuva inikeze ososayensi ukuqonda okuphelele ngalezi zinkinga okubuye kwembule imininingwane yokuthi ubuchopho bethu busebenza kanjani. Baphinde baholela ekwelashweni okuyinoveli abacwaningi abaningi abakholelwa ukuthi kuzotholakala kabanzi kubantu abane-Parkinson phakathi neminyaka emi-5 kuya kweyi-10 ezayo. Kodwa lokhu empeleni kuzoba yinguqulo engu-1.0 yalezi zindlela zokwelapha, njengoba sithuthukisa lezi zindlela zokwelashwa zizosetshenziswa kwezinye izifo kunguqulo 2.0(iminyaka eyi-10 kuye kwengama-20 ezansi nomgwaqo) nakubantu ababonakala bephile saka enguqulweni 3.0(20 kuya ku-30) Iminyaka engama-XNUMX).

Ubuchopho bethu buyingxubevange yama-neurons akhiqiza ama-neurotransmitters aqala ukushaywa kukagesi ageleza ebuchosheni futhi ehle ohlelweni lwethu lwezinzwa oluphakathi ukuze atshele izingxenye ezihlukahlukene zemizimba yethu ukuthi zenzeni. Lezi zindlela ze-neural zibanjwa ndawonye futhi zisekelwa inethiwekhi enkulu yamaseli ahlukene, ngalinye linomsebenzi walo ohlukile kodwa wonke aqondiswe ekugcineni uphila futhi usebenza kahle. Okuningi okwenzeka emizimbeni yethu kuqondwa kahle namuhla, ngaphandle kobuchopho. Kunama-neurons ayizigidi eziyizinkulungwane eziyi-100 ebuchosheni bezinhlobo ezahlukahlukene kanye nokuxhumana okungaphezulu kwe-100 trillion phakathi kwalawo ma-neurons. Babophezelekile kukho konke okwenzayo noyikho. Kuze kube muva nje besinokuncane ukuqonda ukuthi zonke izingcezu ezihlukene zihlangana kanjani, kodwa sibonga kakhulu ngocwaningo oluningiliziwe lwezinkinga zemizwa manje sesiqala ukuqonda ukuthi kusebenza kanjani konke. Eminyakeni ezayo amathuluzi namasu amasha, kanye nokusetshenziswa komshini wokufunda, kuzovumela abacwaningi ukuba baphenye bajule nakakhulu njengoba abaningi bekholelwa ukuthi kuyindaba yesikhathi ngaphambi kokuba sibe nesithombe esiphelele.

Esikwaziyo, ngokucwaninga nokwelashwa kwezinkinga ze-neurodeergenerative ezifana ne-Parkinson, i-Alzheimer's, i-ALS, njll., Ukuthi lapho ama-neurons efa noma izimpawu zamakhemikhali zingasakhiqizwa ngaphesheya komkhawulo othile, izinkinga ziyavela. Esifo sikaParkinson ngokwesibonelo, izimpawu aziveli kuze kube yilapho okungenani ama-50-80% ama-neurons akhiqiza i-dopamine ezingxenyeni ezithile zobuchopho esefile. Noma kunjalo ubuchopho bomuntu wonke buwohloka ngokuhamba kwesikhathi, ukusabalala kwama-radicals mahhala kanye nokuqoqwa kwamaprotheni aphikisiwe okwenzeka esenzweni esilula sokudla nokuphefumula kuholela ekufeni kweseli. Ngamunye wethu unenani elihlukile lama-neurons anempilo ezinhlelweni ezihlukene futhi lesi yisizathu esenza kube nokuhlukahluka okunjalo emandleni abantu okuqonda. Ukusetshenziswa kwezindlela zokwelapha ezithuthukiswayo namuhla ukuze kulungiswe ukushiyeka kubantu abanezifo ezihlukahlukene ngolunye usuku kuzosetshenziswa kubantu abanamazinga aphansi e-neuron ethile engxenyeni ethile yobuchopho.

I-neurodegeneration eholela ezifweni zemizwa ngumkhiqizo we inqubo yokuguga yemvelo. Ukwandisa ukuqwashisa nokuqonda izici ezibangela ukuguga kuye kwaholela enanini elikhulayo labantu emphakathini wezokwelapha abakholelwa ukuthi singangenelela kule nqubo futhi simise noma hlehlisa ukuguga ngokuphelele. Kusetshenzwa amanoveli okwelapha ukubhekana nalezi zinkinga. Ezinye zezinto ezijabulisa kakhulu…

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Wonke la masu asesigabeni sawo sokuqala futhi azobona ukuthuthuka okuqhubekayo eminyakeni ezayo. Kungakholakala ukuthi uma abantu ababonakala bephile kahle sebephelelisiwe bazokwazi ukungena emtholampilo, bahlole ubuchopho babo, bathole ukufunda ukuthi yiziphi izingxenye zobuchopho babo ezinamazinga aphansi futhi bakhethe ukukhuphula lawo mazinga ngeyodwa noma ngaphezulu kwezinhlobonhlobo. amasu okukhulunywe ngenhla.

Kuze kube manje amathuluzi atholakalayo okuqonda kanye nokuhlonza izifo eziningi abengenele ngokudabukisayo futhi noxhaso lwezimali lokucwaninga olunesifiso lushoda. Nokho-ke kunemali eningi namuhla ethelwa ocwaningweni olunjalo futhi baningi abantu abasebenzela ukulwa nalo kunanini ngaphambili. Eshumini leminyaka elizayo sizothola amathuluzi amasha amangalisayo ukusiza ukuqonda kwethu. Amaphrojekthi athembisa kakhulu avela ku- Iphrojekthi yobuchopho bomuntu yaseYurophu futhi Isinyathelo sobuchopho sase-U.S abazama ukwenzela ubuchopho lokho okwenziwa iphrojekthi ye-genome yomuntu ukuze siqonde i-genome. Uma kuphumelele kuzonikeza abacwaningi ukuqonda okungakaze kubonwe ukuthi izingqondo zihlanganiswa kanjani. Ngaphezu kwalokho kube khona uxhaso olukhulu lwamaphrojekthi avela ezikhungweni ezizimele ezifana ne-Google ethuthukisiwe Amalebhu e-Calico, lo Paul Allen Institute for Brain Science, iChan Zuckerberg Initiative, lo Zuckermen ingqondo, ingqondo kanye nokuziphatha Institute, iGladstone Institute, lo I-American Federation for Aging Research, i-Buck Institute, Izikripthi futhi okusho, ukubala abambalwa, ingasaphathwa yonke imisebenzi emisha eyenziwa emanyuvesi nasezinkampanini ezingenisa inzuzo emhlabeni wonke.