ʻO ka lapaʻau ʻana i ka maʻi diabetes e hoʻololi i nā pūnaewele maʻi maʻi i loko o nā pūnaewele hana insulin

Ua hoʻopuka nā mea noiʻi ma ke Kula Lapaʻau o ke Kulanui o Wakinekona ma St. Louis a me Harvard i nā pūnae huna huna insulin mai nā pūnaewele kumu i loaʻa mai nā maʻi me ka maʻi diabetes type 1 (T1D), e hōʻike ana i kahi ala hou loa i ka mālama ʻana i ka T1D ʻaʻole mamao loa i ka wā e hiki mai ana. .

ʻO ka maʻi diabetes type 1 a me ka hiki ke mālama pilikino

ʻO ka maʻi maʻi type 1 (T1D) he maʻi maʻi maʻi kahi e hoʻopau ai ka ʻōnaehana pale o ke kino i nā cell pancreatic hoʻokuʻu i ka insulin - nā cell beta i loko o ka ʻiʻo mokupuni - no laila hiki ʻole i ka pancreas ke hana i ka nui o ka insulin no ka mālama ʻana i ke kō koko maʻamau. 

ʻOiai aia nā lāʻau lapaʻau mua i loaʻa e kōkua i nā poʻe maʻi e hoʻokō i kēia maʻi - e like me ka hoʻomaʻamaʻa a me ka hoʻololi ʻana i ka meaʻai, nā inikini insulin mau, a me ka nānā ʻana i ke koko - ʻaʻohe lāʻau i kēia manawa.

Eia nō naʻe, ʻike ʻia kēia ʻike hou e hiki ke loaʻa i nā lāʻau lapaʻau T1D pilikino i ka wā e hiki mai ana: hilinaʻi ia i nā pūnaewele ponoʻī o ka poʻe maʻi T1D e hana i nā pūnae beta hou e hana ai i ka insulin e kōkua i ka hoʻopaʻa ʻana i nā pae kō. ka mālama pono ʻana no ka mea maʻi a me ka hoʻopau ʻana i ka pono no nā pana insulin maʻamau.

Ka noiʻi a me ka holomua o ka hoʻokaʻawale cell i loko o ke keʻena hoʻokolohua I Vivo a I Vitro ikea ai

Ua hōʻike ʻia nā mea noiʻi ma ke Kula Nui o ka Lapaʻau o ke Kulanui o Wakinekona e hiki i nā pūnaewele hou i loaʻa mai nā pūnaewele kumu ke hana i ka insulin ke loaʻa lākou i ke kō glucose. Ua ho'āʻoʻia nā pūnaewele hou I loko o ka ola ma na iole a me ma ka vitro i nā moʻomeheu, a ma nā hiʻohiʻona ʻelua, ua ʻike nā mea noiʻi ua hūnā lākou i ka insulin i ka pane ʻana i ka glucose.

Ua paʻi ʻia ka noiʻi o nā ʻepekema ma ka Nature Communications journal ma Mei 10, 2016:

"Ma ke kumumanaʻo, inā hiki iā mākou ke hoʻololi i nā cell i hōʻino ʻia i loko o kēia mau kānaka me nā cell beta pancreatic hou - nona ka hana nui e mālama a hoʻokuʻu i ka insulin e kāohi ai i ka glucose koko - ʻaʻole pono nā poʻe maʻi me ka maʻi diabetes type 1 i nā pana insulin," wahi a Jeffrey R. Millman (PhD), ka mea kākau mua a me ke kaukaʻi kumu o ka lāʻau lapaʻau a me ka ʻenekinia biomedical ma ke kula ʻo Washington University School of Medicine. "ʻO nā pūnaewele a mākou i hana ai ke ʻike nei i ka hele ʻana o ka glucose a huna i ka insulin i ka pane ʻana. A ʻoi aku ka maikaʻi o ka hana ʻana o nā cell beta i ka mālama ʻana i ke kō koko ma mua o nā mea maʻi maʻi maʻi."

Ua hana ʻia nā hoʻokolohua like ma mua akā ua hoʻohana wale ʻia nā cell stem mai nā poʻe me ka maʻi diabetes. Ua hiki mai ka holomua i ka wā i hoʻohana ai ka poʻe noiʻi i nā cell beta mai ka ʻili ʻili o ka poʻe maʻi me T1D a ʻike ʻo ia, ʻoiaʻiʻo, hiki ke hoʻokaʻawale ʻia nā cell stem o nā maʻi T1D i loko o nā pūnaewele hana insulin.

"He mau nīnau e pili ana inā hiki iā mākou ke hana i kēia mau cell mai ka poʻe me ka maʻi diabetes type 1," wehewehe ʻo Millman. "Ua manaʻo kekahi poʻe ʻepekema no ka hele ʻana mai o ka ʻiʻo mai nā maʻi maʻi diabetes, aia paha nā hemahema e pale aku ai iā mākou mai ke kōkua ʻana i nā cell stem e hoʻokaʻawale i nā cell beta.

Ka hoʻokō ʻana i nā cell beta i hoʻokaʻawale ʻia i ka maʻi T1D stem-cell no ka mālama ʻana i ka maʻi diabetes 

ʻOiai ʻo ka noiʻi a me ka ʻike e hōʻike ana i ka ʻōlelo hoʻohiki nui i ka wā e hiki mai ana, ʻōlelo ʻo Millman e pono ana ka noiʻi hou ʻana e hōʻoia i ka hana ʻole ʻana o nā maʻi maʻi ma muli o ka hoʻohana ʻana i nā cell stem i loaʻa i ka maʻi T1D. Hoʻoulu ʻia ka puʻupuʻu i kekahi manawa ma ka noiʻi ʻana o ka stem cell,  ʻoiai ʻaʻole i hōʻike ʻia nā ʻiole o ka mea noiʻi i nā ʻiole a hiki i hoʻokahi makahiki ma hope o ka hoʻokomo ʻia ʻana o nā cell.

Ua ʻōlelo ʻo Millman, hiki ke mākaukau nā cell beta i loaʻa i ka stem cell no nā hoʻokolohua kanaka ma kahi o ʻekolu a ʻelima mau makahiki. ʻO ke kaʻina hana ʻokiʻoki liʻiliʻi e pili ana i ka hoʻokomo ʻana i nā sela ma lalo o ka ʻili o nā maʻi, e ʻae ana i nā cell e komo i ke koko e hoʻoponopono ai i ke kiʻekiʻe o ke kō.

"ʻO ka mea a mākou e noʻonoʻo nei he hana maʻi waho kahi e waiho ʻia ai kekahi ʻano mea i hoʻopiha ʻia me nā cell ma lalo o ka ʻili," wahi a Millman.

Hoʻomaopopo pū ʻo Millman e hiki ke hoʻohana ʻia ka ʻenehana hou i nā ʻano like ʻole e mālama ai i nā maʻi ʻē aʻe. Ma muli o ka hōʻike ʻana o Millman a me kāna mau hoa hana he hiki ke hoʻokaʻawale i nā cell beta mai nā cell stem i nā poʻe T1D, ʻōlelo ʻo Millman aia paha ka hana ʻana o kēia ʻano hana i nā poʻe maʻi me nā ʻano maʻi ʻē aʻe - me (akā ʻaʻole i kaupalena ʻia. i) maʻi maʻi type 2, maʻi diabetes neonatal (diabetes i nā keiki hānau hou), a me Wolfram Syndrome.

ʻAʻole hiki ke mālama i ka T1D i loko o kekahi mau makahiki, akā hiki nō ke hoʻomohala i nā lāʻau lapaʻau hou no nā maʻi pili a me ka hoʻāʻo ʻana i ka hopena o nā lāʻau maʻi maʻi ma luna o nā pūnaewele ʻokoʻa o kēia mau maʻi.