Phekolo ea lefu la tsoekere e fetolang lisele tsa lefu la tsoekere hore e be lisele tse hlahisang insulin

Bafuputsi ba Washington University School of Medicine e St. Louis le Harvard ba hlahisitse lisele tse hlahisang insulin ho tsoa liseleng tsa stem tse tsoang ho bakuli ba nang le lefu la tsoekere la mofuta oa 1 (T1D), ba fana ka maikutlo a hore mokhoa o mocha oa ho phekola T1D ha o hole haholo nakong e tlang. .

Mofuta oa 1 oa lefu la tsoekere le monyetla oa kalafo ea motho ka mong

Mofuta oa 1 oa lefu la tsoekere (T1D) ke boemo bo sa foleng boo sesole sa 'mele se senyang lisele tsa pancreatic tse lokollang insulin - lisele tsa beta tse ka har'a lithane tsa islet - ka hona, manyeme a sitoa ho hlahisa insulin e lekaneng ho boloka maemo a tloaelehileng a tsoekere maling. 

Le hoja ho na le liphekolo tse seng li ntse li le teng ho thusa bakuli ho sebetsana ka katleho le boemo bona - tse kang boikoetliso le ho fetola lijo, liente tsa kamehla tsa insulin, le ho hlahloba khatello ea mali - hona joale ha ho na pheko.

Leha ho le joalo, tšibollo ena e ncha e fana ka maikutlo a hore liphekolo tsa motho ka mong tsa T1D li ka ba teng nakong e tlang e seng hole haholo: e itšetlehile ka lisele tsa stem tsa bakuli ba T1D ho hlahisa lisele tse ncha tsa beta tse etsang insulin ho thusa ho laola maemo a tsoekere, ka hona, kalafo e iphelisang bakeng sa mokuli le ho felisa tlhoko ea lithunya tsa kamehla tsa insulin.

Patlisiso le katleho ea phapang ea lisele ka laboratoring Vivo 'me In Vitro ho etsa diteko

Bafuputsi ba Sekolo sa Bongaka sa Univesithi ea Washington ba bontšitse hore lisele tse ncha tse tsoang liseleng tsa stem li ka hlahisa insulin ha li kopana le tsoekere ea tsoekere. Lisele tse ncha li ile tsa lekoa Ka vivo ka litoeba le a vitro litsong, le maemong ao ka bobeli, bafuputsi ba fumane hore ba hlahisitse insulin ho arabela tsoekere.

Lipatlisiso tsa bo-rasaense li ile tsa hatisoa ho Koranta ea Nature Communications ka la 10 Mots'eanong 2016:

"Ka khopolo, haeba re ne re ka nkela lisele tse senyehileng ho batho bana sebaka ka lisele tse ncha tsa "pancreatic beta" - tseo mosebetsi oa tsona oa mantlha e leng ho boloka le ho lokolla insulin ho laola tsoekere ea mali - bakuli ba nang le lefu la tsoekere la mofuta oa 1 ba ke ke ba hlola ba hloka lithunya tsa insulin. ho boletse Jeffrey R. Millman (PhD), mongoli oa pele le motlatsi oa moprofesa oa meriana le boenjiniere ba likokoana-hloko Sekolong sa Bongaka sa Washington University. "Lisele tseo re li entseng li utloa boteng ba tsoekere 'me li hlahisa insulin ka lebaka la eona. 'Me lisele tsa beta li etsa mosebetsi o motle haholo oa ho laola tsoekere ho feta kamoo bakuli ba lefu la tsoekere ba ka khonang."

Liteko tse ts'oanang li kile tsa etsoa empa li sebelisitse lisele tsa stem tse tsoang ho batho ba se nang lefu la tsoekere. Katleho e etsahetse ha bafuputsi ba ne ba sebelisa lisele tsa beta tse tsoang liseleng tsa letlalo tsa bakuli ba T1D mme ba fumana hore ehlile hoa khoneha hore lisele tsa stem tsa bakuli ba T1D li khetholle lisele tse hlahisang insulin.

"Ho bile le lipotso mabapi le hore na re ka etsa lisele tsena ho tsoa ho batho ba nang le lefu la tsoekere la mofuta oa 1," ho hlalositse Millman. "Bo-rasaense ba bang ba ne ba nahana hore kaha lisele li ne li tla tsoa ho bakuli ba lefu la tsoekere, ho ka 'na ha e-ba le mefokolo ea ho re thibela ho thusa lisele tsa stem ho arola lisele tsa beta. Hoa etsahala hore ha ho joalo."

Ts'ebetsong ea lisele tsa beta tse arohaneng tsa mokuli oa T1D ho phekola lefu la tsoekere 

Le hoja lipatlisiso le ho sibolloa li bontša tšepiso e kholo nakong e tlang e haufi, Millman o re lipatlisiso tse ling lia hlokahala ho netefatsa hore lihlahala ha li thehoe ka lebaka la ho sebelisa lisele tse bakoang ke mokuli tsa T1D. Ka linako tse ling lihlahala li hlaha nakong ea lipatlisiso tsa stem cell,  le hoja liteko tsa mofuputsi ho litoeba li sa bontše bopaki ba lihlahala ho fihlela selemo ka mor'a hore lisele li kenngoe.

Millman o re lisele tsa beta tse tsoang ho lisele tsa stem li ka be li loketse liteko tsa batho nakong ea lilemo tse tharo ho isa ho tse hlano. Opereishene e sa hlaseleng hanyane e tla kenyelletsa ho kenya lisele ka tlas'a letlalo la bakuli, ho lumella lisele ho fumana phepelo ea mali ho laola maemo a tsoekere ea mali.

"Seo re se nahanang ke ts'ebetso ea bakuli ba kantle moo sesebelisoa se tlatsitsoeng ka lisele se tla beoa ka tlasa letlalo," ho boletse Millman.

Millman o boetse o bolela hore mokhoa ona o mocha o ka sebelisoa ka litsela tse sa tšoaneng ho phekola maloetse a mang. Kaha liteko tsa Millman le basebetsi-'moho le eena li pakile hore hoa khoneha ho arola lisele tsa beta ho lisele tsa stem ho batho ba T1D, Millman o re ho na le monyetla oa hore mokhoa ona o sebetse le ho bakuli ba nang le mefuta e meng ea lefu lena - ho kenyeletsoa (empa e sa lekanyetsoe). ho) mofuta oa 2 lefu la tsoekere, lefu la tsoekere le sa tsoa tsoaloa (lefu la tsoekere ho bana ba sa tsoa tsoaloa), le Wolfram Syndrome.

Hase feela hore ho ka khoneha ho phekola T1D ka mor'a lilemo tse 'maloa, empa hape ho ka khonahala ho nts'etsapele liphekolo tse ncha tsa mafu a amanang le ho lekola phello ea lithethefatsi tsa lefu la tsoekere liseleng tse arohaneng tsa lisele tsa stem tsa bakuli bana.