ʻO ka mea hana puhi momona hou

Hoʻopiʻi mau ʻia nā calorie no ka hoʻoikaika ʻana i kā mākou mau lole a ʻoi aku ka paʻakikī o kā mākou hoʻoholo meaʻai wikiwiki; ua lilo lākou i mau ʻenemi no mākou ma ka hale haʻuki. Eia nō naʻe, hiki i ka ʻepekema ke hoʻihoʻi i ka inoa o nā calorie i ka wā e hiki mai ana. Ua nānā nā mea noiʻi ma ka Dana-Farber Cancer Institute a me ke Kulanui o Kaleponi, Berkeley, i nā cell e hiki ke puhi i nā calorie a kipaku iā lākou e like me ka wela ma mua o ka mālama ʻana iā lākou i momona no ka hoʻohana hope.

ʻO ka enzyme i loko o nā pūnaewele o nā ʻiole, PM20D1, e hōʻiliʻili i ka lawa e koi ai i kahi amino acid, N-acyl, e hana ʻia i loko o ke kino. ʻO ka N-acyl, ke loaʻa i loko o nā kaʻina metabolic, pono e lawe ʻia ka glucose i loko, akā ʻaʻole ia e hoʻopuka i ka adenosine triphosphate (ATP). Mālama ʻia ka ATP ma ke ʻano he kumu no ke kino e komo i ka ikehu.

I ka hihia o kēia mau pūnaewele hou, ʻo ka nele o ka ATP e alakaʻi i nā cell e pono e ʻimi koke i ka ikehu mai kahi kumu ʻē aʻe. ʻO nā sela ʻeleʻele, a i ʻole nā ​​​​pūnaewele me ka waihoʻoluʻu ʻeleʻele ma muli o ka nui o ka mitochondria, ʻo ia nā ʻano kikoʻī o nā cell i hopu i ka manaʻo o ka Dana-Farber a me UC, Berkeley, nā ʻepekema. Ma muli o ka nele o kēia mau ʻeleʻele ʻeleʻele i ka ATP, ua ʻike ʻia lākou no ko lākou hiki ke puhi mua i nā calorie mai ka momona, i mea e komo koke ai i ka ikehu no nā kaʻina metabolic. ʻOiai e puhi ʻia ana ka momona, hoʻokuʻu ʻia ka wela ma ke ʻano he ʻōpala a ʻaʻole mālama ʻia i loko o ke kino no ka hoʻohana ʻana ma hope. E like me ka mea e pono ai ke komo i ka ikehu, akā, ʻaʻole hana i ka ATP, pono e hilinaʻi nā cell i ka momona ma ke ʻano mua e loaʻa koke ai ka ikehu. Ke hoʻohana koke ʻia ka momona, ʻaʻole loaʻa i ke kino ka manawa e mālama ai ia mea no ka wā ma hope.

Ua nui ka ikaika e wehewehe ai. ʻO ka nūhou maikaʻi, hiki iā mākou ke hoʻopili hou i ko mākou ola i kēlā me kēia lā. Ke ʻai a ʻeli mākou i ka pasta, no ka laʻana, ʻimi ko mākou kino i ka ikehu e hoʻohana ai i kā mākou kaʻina metabolic. No ka mea, ʻo ka carbohydrates (i loko o ka pasta) ka mea maʻalahi no ke kino e wāwahi, lilo lākou i ala maʻalahi a ʻoluʻolu no ko mākou kino e komo i ka ikehu. Pēlā nō, hilinaʻi nā pūnaewele me N-acyl i ka puhi ʻana i nā calorie mai ka momona ma ke ʻano he ala wikiwiki loa e loaʻa ai ka ikehu ke hele ʻole ʻo ATP.