Ho koala pheko: Ho etsa hore immunotherapy e sebetse haholoanyane

Ho thoe'ng haeba pheko ea mofetše e ne e le sesole sa hau sa 'mele? Ho entsoe lipatlisiso tse ngata ho etsa hore seo e be 'nete. Kalafo e bitsoa immunotherapy, moo lisele tsa hau tsa T li fetotsoeng liphatsa tsa lefutso ho khetholla lisele tsa mofetše le ho li senya.

Empa kalafo ena hajoale e turu haholo ebile e nka nako, ka hona lipatlisiso li kene ho etsa hore immunotherapy e fumanehe le ho sebetsa haholoanyane. Ho a phuputso ea morao tjena e hatisitsoeng koranteng ea Science Translational Medicine, ho tlalehoa hore sehlopha sa bo-rasaense ba Brithani se "phekola" masea a mabeli a kankere ea mali (kankere ea mali) ho sebelisa immunotherapy. Leha thuto e na le mefokolo e kgolo, e bontšitse tharollo e ka khonehang ea ho sebetsa li-kinks tsa phekolo ka ho sebelisa a mokhoa o mocha oa ho fetola liphatsa tsa lefutso o bitsoang TALENS.

Ho shebisisa immunotherapy

Phekolo ea lisele tsa CAR T ke mofuta oa immunotherapy o ntseng o nahanoa sechabeng sa mofetše. E emetse chimeric antigen receptor T cell. Kalafo ena e akarelletsa ho ntša lisele tse ling tsa T (lisele tse tšoeu tsa mali tse khethollang le ho bolaea bahlaseli) maling a mokuli. Lisele tseo li fetoloa liphatsa tsa lefutso ka ho kenya li-receptor tse khethehileng holim'a tsona tse bitsoang CAR. Joale lisele li khutlisetsoa maling a mokuli. Joale li-receptor li batla lisele tsa tumor, li ikamahanye le tsona ebe li li bolaea. Kalafo ena e sebetsa feela litekong tsa bongaka, leha lik'hamphani tse ling tsa lithethefatsi li rera ho etsa hore kalafo e fumanehe nakong ea selemo.

Kalafo ena e sebelitse hantle ho bakuli ba bacha ba leukemia. Lehlakore le tlase? E bitsa chelete e ngata ebile e ja nako. Sehlopha se seng le se seng sa lisele tsa T tse fetotsoeng se hloka ho etsoa ka mokhoa o ikhethileng bakeng sa mokuli e mong le e mong. Ka linako tse ling bakuli ha ba na lisele tsa T tse phetseng hantle tse ka etsang hore sena se qale. Ho fetola liphatsa tsa lefutso ho rarolla a mang a mathata ana.

Tse ncha ke life?

Ho fetola liphatsa tsa lefutso ke ho fetola liphatsa tsa lefutso ho DNA ea motho. Boithuto ba morao-rao bo sebelisitse mokhoa o mocha oa ho fetola liphatsa tsa lefutso o bitsoang TALENS. Sena se etsa hore lisele tsa T e be tsa bokahohleng, ho bolelang hore li ka sebelisoa ho mokuli leha e le ofe. Ha ho bapisoa le lisele tsa T tse entsoeng ka tloaelo, ho etsa lisele tsa T tsa bokahohleng ho fokotsa nako le chelete tse hlokahalang ho phekola bakuli.

Ho fetola liphatsa tsa lefutso ho boetse ho sebelisoa ho tlosa litšitiso tse etsang hore phekolo ea lisele tsa CAR T e se sebetse hantle. Bafuputsi Univesithing ea Pennsylvania hajoale ba ntse ba etsa lipatlisiso ka mekhoa ea ho sebelisa mokhoa oa ho fetola liphatsa tsa lefutso CRISPR ho fetola liphatsa tsa lefutso tse peli tse bitsoang li-checkpoint inhibitors tse thibelang phekolo ea CAR T cell ho sebetsa hantle kamoo e lokelang. Teko e tlang e tla sebelisa bakuli ba batho.